US2018179175A1PendingUtilityA1

Processes for preparing antiviral compounds

Assignee: GILEAD PHARMASSET LLCPriority: Jun 11, 2014Filed: Dec 19, 2017Published: Jun 28, 2018
Est. expiryJun 11, 2034(~7.9 yrs left)· nominal 20-yr term from priority
A61P 31/14C07D 405/12C07C 49/80C07D 491/052C07D 311/78C07D 207/16A61K 31/4188C07D 405/14C07C 49/755C07C 2602/10C07C 49/82
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Claims

Abstract

The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

Claims

exact text as granted — not AI-modified
1 .- 134 . (canceled) 
     
     
         135 . A compound of formula (L): 
       
         
           
           
               
               
           
         
         wherein Z is hydrogen, halo, —OSO 2 R 1 , —BF 3   − , —B(OR 2 ) 2 , —CO 2 H, or —NR 1   3  wherein R 1  is alkyl, haloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, and R 2  is alkyl. 
       
     
     
         136 . The compound of  claim 135 , wherein Z is bromo. 
     
     
         137 . A compound of formula (Q): 
       
         
           
           
               
               
           
         
       
     
     
         138 . (canceled) 
     
     
         139 . A compound of formula (M-a): 
       
         
           
           
               
               
           
         
       
     
     
         140 . A compound of formula (M-b):

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