Composition for promoting hair growth containing novel pantetheine derivative

Abstract

Provided is a composition for promoting hair growth, containing, as an active ingredient, a new compound represented by the following formula 1 or a salt thereof, which exhibits an excellent effect of promoting the growth of dermal papilla cells to thereby exhibit the effect of promoting hair growth: wherein R is any one selected from the group consisting of 2-methylbutyryl, 3-methylbutyryl, cinnamoyl, 4-pentenoyl, 10-undecenoyl, isobutyl formate, 2,4-dihydroxybenzoyl, geranyl, farnesyl, acryloyl, propanone, 2-pentanone, 1-(4-hydroxyphenyl)ethanone, 1-(2,4-dihydroxyphenyl)ethanone, pentanoic acid, 2-hydroxypropanoic acid, 2-phenylacetic acid, 2-(4-(propanoyl)phenyl)acetic acid, 4-methylbenzoic acid, 4-(4-phenyl)-4-oxobutanoic acid, 2-oxoethyl acetyl, 2-phenoxyacetyl, 2-(benzyloxy)acetyl, 4-methoxybenzoyl, 3,5-dimethylphenol, 6-methoxybenzene-1,4-diol, propenylbenzene, and 4-hydroxycoumarin.

1 . A composition for promoting hair growth, containing, as an active ingredient, a compound represented by the following formula 1 or a salt thereof: 
       
         
           
           
               
               
           
         
       
       wherein R is any one selected from the group consisting of 2-methylbutyryl, 3-methylbutyryl, 4 pentenoyl, 10-undecenoyl, isobutyl formate, and 2,4-dihydroxybenzoyl. 
     
     
         2 . The composition of  claim 1 , wherein the compound represented by formula 1 is any one selected from the group consisting of 2-methylbutyryl-D-pantetheine, 3-methylbutyryl-D-pantetheine, 4 pentenoyl-D-pantetheine, 10-undecenoyl-D-pantetheine, isobutyl formate-D-pantetheine, and 2,4-dihydroxybenzoyl-D-pantetheine. 
     
     
         3 . The composition of  claim 1 , wherein the compound represented by formula 1 exhibits an effect of promoting growth of dermal papilla cells. 
     
     
         4 . The composition of  claim 1 , wherein the compound represented by formula 1 is prepared using D-pantethine as a starting material. 
     
     
         5 . The composition of  claim 1 , wherein the composition is a cosmetic composition for preventing hair loss and promoting hair growth. 
     
     
         6 . The composition of  claim 5 , wherein the cosmetic composition has any one formation selected from the group consisting of hair tonics, hair conditioners, hair essence, hair lotion, hair nourishing lotion, hair shampoo, hair rinse, hair treatments, hair cream, hair nourishing cream, hair moisturizer cream, hair massage cream, hair wax, hair aerosols, hair packs, hair nourishing pack, hair soap, hair cleansing foam, hair oil, hair drying preparations, hair preservation treatments, hair colorants, hair weaving preparations, color-removing preparations for hair, hair gel, hair glazes, hair dressingers, hair lacquers, hair moisturizers, hair mousse, and hair sprays. 
     
     
         7 . The composition of  claim 1 , wherein the composition is a pharmaceutical composition for preventing hair loss and promoting hair growth. 
     
     
         8 . The composition of  claim 7 , wherein the pharmaceutical composition has any one formation selected from the group consisting of ointments, pastes, gels, jellies, serums, aerosol sprays, non-aerosol sprays, foams, creams, lotions, solutions, and suspensions.