Applications for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products

Abstract

This invention discloses uses for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products. This invention provides uses for estradiol in preparing anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma products. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug estradiol, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that estradiol has a new use as an anti-small cell lung cancer and/or ovarian cancer and/or osteosarcoma medication, thus achieving a new purpose for an old drug.

1 - 9 . (canceled) 
     
     
         10 . A method for treating small cell lung cancer in a subject comprising administering an effective amount of estradiol to the subject. 
     
     
         11 . A method for treating ovarian cancer in a subject comprising administering an effective amount of estradiol to the subject. 
     
     
         12 . A method for treating osteosarcoma in a subject comprising administering an effective amount of estradiol to the subject. 
     
     
         13 . A method of inhibiting the proliferation of small cell lung cancer cells comprising contacting the cells with an effective amount of estradiol. 
     
     
         14 . The method of  claim 13 , wherein the lung cancer cells are NCI-H82. 
     
     
         15 . A method of inhibiting the proliferation of ovarian cancer cells comprising contacting the cells with an effective amount of estradiol. 
     
     
         16 . The method of  claim 15 , wherein the ovarian cancer cells are SKOV-3 cells. 
     
     
         17 . A method of inhibiting the proliferation of osteosarcoma cells comprising contacting the cells with an effective amount of estradiol. 
     
     
         18 . The method of  claim 17 , wherein the osteosarcoma cells are U2OS cells. 
     
     
         19 . A pharmaceutical composition for use in treating small cell lung cancer comprising estradiol. 
     
     
         20 . A pharmaceutical composition for use in treating ovarian cancer comprising estradiol. 
     
     
         21 . A pharmaceutical composition for use in treating osteosarcoma comprising estradiol. 
     
     
         22 . A kit comprising the pharmaceutical composition of  claim 19  and instructions for use in treating small cell lung cancer. 
     
     
         23 . A kit comprising the pharmaceutical composition of  claim 20  and instructions for use in treating ovarian cancer. 
     
     
         24 . A kit comprising the pharmaceutical composition of  claim 21  and instructions for use in treating osteosarcoma.