Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid

Abstract

Disclosed are pharmaceutical compositions containing clodronic acid and hyaluronic acid or their salts as active constituents, mixed with suitable vehicles.

1 - 17 . (canceled) 
     
     
         18 . A method of treatment of osteoarthritis, the method comprising administering by intra-articular route to a subject in need thereof a combination of clodronic acid or its salts and hyaluronic acid or its salts in the form of a pharmaceutical injectable solution comprising from 0.5 to 2 mg of clodronic acid or its salts and from 5 to 30 mg of hyaluronic acid having a molecular weight of between 0.4 and 1.5×10 3  kDa or its salts and suitable vehicles. 
     
     
         19 . The method as claimed in  claim 18 , wherein said pharmaceutical injectable solution is administered through a disposable syringe. 
     
     
         20 . The method as claimed in  claim 18 , comprising 1 mg of clodronic acid or its salts. 
     
     
         21 . The method as claimed in  claim 18 , comprising sodium clodronate. 
     
     
         22 . The method as claimed in  claim 18 , comprising 20 mg of hyaluronic acid or its salts. 
     
     
         23 . The method as claimed in  claim 18 , wherein the solution comprises sodium hyaluronate. 
     
     
         24 . The method as claimed in  claim 18 , wherein the solution comprises sodium clodronate and sodium hyaluronate. 
     
     
         25 . The method as claimed in  claim 18 , wherein said administration is carried out once a week. 
     
     
         26 . The method as claimed in  claim 25 , wherein said once a week administration is carried out once a week for three weeks. 
     
     
         27 . The method as claimed in  claim 18 , wherein the pharmaceutical injectable solution has a total volume of between 0.5 and 5 ml. 
     
     
         28 . The method as claimed in  claim 27 , wherein the pharmaceutical injectable solution has a total volume of 2 ml. 
     
     
         29 . A method of treatment of osteoarthritis, the method comprising administering by intra-articular route to a subject in need thereof a combination of clodronic acid or its salts and hyaluronic acid or its salts in the form of a pharmaceutical injectable solution comprising from 3 to 5 mg of clodronic acid or its salts and from 5 to 30 mg of hyaluronic acid having a molecular weight of between 0.4 and 1.5×10 3  kDa or its salts and suitable vehicles. 
     
     
         30 . The method as claimed in  claim 29 , comprising 3 mg of clodronic acid or its salts. 
     
     
         31 . The method as claimed in  claim 29 , comprising 25 mg of hyaluronic acid or its salts. 
     
     
         32 . The method as claimed in  claim 29 , wherein said administration is carried out once a week. 
     
     
         33 . The method as claimed in  claim 29 , wherein the pharmaceutical injectable solution has a total volume of between 2 and 3 ml. 
     
     
         34 . The method as claimed in  claim 29 , wherein the pharmaceutical injectable solution has a total volume of 2.5 ml.