Qsox1 as an anti-neoplastic drug target

Abstract

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

What is claimed is: 
     
         1 . A method for tumor treatment, comprising administering to a subject having a tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to treat the tumor, wherein the tumor is a pancreatic tumor that over-expresses QSOX1 compared to control. 
     
     
         2 . A method for pancreatic tumor treatment, comprising administering to a subject having a pancreatic tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to treat the pancreatic tumor. 
     
     
         3 . The method of  claim 2 , wherein the pancreatic tumor comprises a pancreatic adenocarcinoma. 
     
     
         4 . A method for breast tumor treatment, comprising administering to a subject having a breast tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to treat the breast tumor. 
     
     
         5 . The method of  claim 4 , wherein the tumor is an estrogen receptor positive (ER+) breast tumor. 
     
     
         6 . The method of  claim 4 , wherein the breast tumor is a Luminal B breast tumor. 
     
     
         7 . The method of  claim 2 , wherein the method limits tumor metastasis. 
     
     
         8 . A method inhibiting tumor metastasis, comprising administering to a subject having a breast tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to inhibit metastasis of the breast tumor. 
     
     
         9 . The method of  claim 8 , wherein the tumor is a cytokeratin 5/6 negative breast tumor, or a Luminal B breast tumor. 
     
     
         10 . A method inhibiting tumor metastasis, comprising administering to a subject having a pancreatic tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to inhibit metastasis of the pancreatic tumor.