Spray dry formulations

Abstract

Disclosed herein are compounds, compositions, methods and formulations therefor, for preventing and treating proliferative diseases associated with aberrant receptor tyrosine kinase (RTK) activity. The therapeutic formulations described herein more specifically relate to the non-selective inhibition of RTKs associated with vascular and pulmonary disorders.

1 - 76 . (canceled) 
     
     
         77 . A formulation comprising:
 a) a compound of the formula:   
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt thereof; and 
         b) at least one excipient, 
       
       wherein the formulation is a powder. 
     
     
         78 . The formulation of  claim 77 , wherein the formulation is a dry powder. 
     
     
         79 . The formulation of  claim 78 , wherein the dry powder has a moisture content below about 5% by water weight. 
     
     
         80 . The formulation of  claim 77 , wherein the excipient is a hydrophobic amino acid. 
     
     
         81 . The formulation of  claim 80 , wherein the hydrophobic amino acid is leucine. 
     
     
         82 . The formulation of  claim 81 , wherein the hydrophobic amino acid is L-leucine. 
     
     
         83 . The formulation of  claim 77 , wherein the excipient is a carbohydrate bulking agent. 
     
     
         84 . The formulation of  claim 83 , wherein the carbohydrate bulking agent is trehalose. 
     
     
         85 . The formulation of  claim 77 , wherein the formulation comprises two excipients. 
     
     
         86 . The formulation of  claim 85 , wherein the excipients are leucine and trehalose. 
     
     
         87 . The formulation of  claim 77 , wherein the powder has an average particle size of about 0.5 to 10 microns. 
     
     
         88 . The formulation of  claim 77 , wherein the compound is present in an amount from 12.67% to 61.73%. 
     
     
         89 . A method of treating a condition in a subject in need thereof, the method comprising administering to the subject a formulation comprising:
 a) a therapeutically-effective amount of a compound of the formula:   
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt thereof; and 
         b) at least one excipient, 
       
       wherein the formulation is a powder. 
     
     
         90 . The method of  claim 89 , wherein the administration is by inhalation. 
     
     
         91 . The method of  claim 89 , wherein the administration is intranasal. 
     
     
         92 . The method of  claim 89 , wherein the administration is by an inhaler. 
     
     
         93 . The method of  claim 89 , wherein the administration is by a nebulizer. 
     
     
         94 . The method of  claim 89 , wherein the administration is by an atomizer. 
     
     
         95 . The method of  claim 89 , wherein the therapeutically-effective amount of the compound is from about 0.01 mg/kg to about 100 mg/kg per day. 
     
     
         96 . The method of  claim 89 , wherein the formulation provides a C max  of about 1 to 5000 ng/mL of the compound in the subject's plasma after administration to the subject. 
     
     
         97 . The method of  claim 89 , wherein the formulation provides a C max  of about 1 to 5000 ng/mL of the compound in the subject's plasma 24 h after administration to the subject.