Method of Treating or Preventing Pathologic Effects of Acute Increases in Hyperglycemia and/or Acute Increases of Free Fatty Acid Flux

Abstract

One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.

1 - 6 . (canceled) 
     
     
         7 . A method of treating a skin wound in a subject comprising applying DFO directly to the wound in an amount effective to increase neovascularization and healing of the wound. 
     
     
         8 . The method of  claim 7  wherein DFO is injected subcutaneously. 
     
     
         9 . The method of  claim 7  wherein DFO is applied transdermally. 
     
     
         10 . The method of  claim 7  wherein the subject is a diabetic subject. 
     
     
         11 . The method of  claim 7  wherein the wound is a chronic wound. 
     
     
         12 . The method of  claim 7  wherein the wound is an acute wound.