Food and/or feed compositions for preventing and treating inflammatory diseases

Abstract

This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of food and/or feed compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.

1 . Esterified pectin or a mixture of esterified pectins for the use in the treatment of immune-mediated diseases and inflammatory diseases in patients, wherein the esterified pectin or the esterified pectins in the mixture have a degree of esterification (DE) of less than 65%. 
     
     
         2 . Esterified pectin according to  claim 1 , wherein the DE of the pectin is less than 60%. 
     
     
         3 . Esterified pectin according to  claim 1 , wherein the DE of the pectin is less than 55%. 
     
     
         4 . Esterified pectin according to  claim 1 , wherein the DE of the pectin is less than 50%. 
     
     
         5 . Esterified pectin according to  claim 1 , wherein the pectin is not amidated. 
     
     
         6 . Esterified pectin according to  claim 1 , wherein the DE of the pectin is at least 1%, preferably at least 2%, more preferably at least 3%. 
     
     
         7 . Esterified pectin or a mixture of esterified pectins for the use in the treatment of immune-mediated diseases and inflammatory diseases to  claim 1 , wherein immune-mediated disease and inflammatory disease is caused by activation of TLR2 by an excessive or undesirable permeability of a tissue containing tight junctions. 
     
     
         8 . Esterified pectin or a mixture of esterified pectins according to  claim 1  for the use in preventing negative side effects of drugs. 
     
     
         9 . The use according to  claim 1 , wherein the patient means a human or other animal likely to develop or suffering from inflammatory disease 
     
     
         10 . Esterified pectin or a mixture of esterified pectins according to  claim 1  for the use in the treatment of immune-mediated diseases and inflammatory diseases and for the use in preventing negative side effects of drugs in patients, wherein the patient is a human avian, bovine, canine, equine, galline, feline, hircine, lapine, murine, musteline, ovine, piscine, porcine and vulpine animals. Preferably, the patient is a human, bovine, canine, feline, galline, ovine, porcine or avian 
     
     
         11 . Use of at least one pectin having a degree of esterification of less than 65% in a food or feed formulation. 
     
     
         12 . A formulation comprising at least one pectin having a degree of esterification (DE) of less than 65%. 
     
     
         13 . Formulation according to  claim 12 , which is a food or a feed formulation.