ESTROGEN RECEPTOR Beta PARTIAL AGONIST HAVING ESTROGEN RECEPTOR Alpha INHIBITORY EFFECT, AND GYNECOLOGICAL DISEASE THERAPEUTIC AGENT USING SAME

Abstract

[Problem] To provide a therapeutic agent for estrogen-dependent gynecological diseases such as endometriosis, uterine fibroids, and uterus adenomyosis. [Solution] To use an estrogen receptor α-inhibiting β partial agonist represented by the formula (a), a pharmaceutically-acceptable salt thereof, or a hydrate of either of the afore-mentioned, as an active ingredient.

1 . An estrogen receptor α-inhibiting β partial agonist represented by the following formula (a); 
       
         
           
           
               
               
           
         
       
     
     
         2 . A gynecological disease therapeutic agent comprising the estrogen receptor α inhibiting β partial agonist of  claim 1 , a pharmaceutically acceptable salt thereof, or a hydrate of the afore-mentioned as an active ingredient. 
     
     
         3 . The gynecological disease therapeutic agent according to  claim 2 , wherein the gynecological disease comprises endometriosis, uterine fibroids, and/or uterus adenomyosis.