Treatment to promote wound healing

Abstract

The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.

What is claimed is: 
     
         1 .- 16 . (canceled) 
     
     
         17 . A method of accelerating the repair of tissue injury and/or reducing inflammation caused by acne in a subject, the method comprising:
 i. identifying the patient exhibiting tissue injury and/or inflammation caused by acne, and   ii. administering to said patient a helminthic parasite preparation consisting essentially of excretory/secretory (ES) product and at least one pharmaceutically acceptable topical carrier or excipient,   wherein said administering step is repeated until the levels of said inflammation are reduced by at least 90%.   
     
     
         18 . A method according to  claim 17 , wherein the excretory/secretory (ES) product is excretory/secretory (ES) product or an immune triggering portion thereof of  Nippostronglyus brasiliensis  (Nb). 
     
     
         19 . A method according to  claim 17 , wherein the administration is topical. 
     
     
         20 . A method according to  claim 17 , wherein the administering step occurs more than once. 
     
     
         21 . A method according to  claim 17 , wherein the tissue injury caused by acne is an open acne lesion. 
     
     
         22 . A method according to  claim 17 , wherein the tissue injury caused by acne is a closed acne lesion. 
     
     
         23 . A composition for accelerating the repair of tissue injury and/or reducing inflammation caused by acne in a subject, the composition comprising an excretory/secretory (ES) product and a pharmaceutically acceptable topical carrier or excipient. 
     
     
         24 . A composition according to  claim 23 , wherein the composition comprises an excretory/secretory (ES) product or an immune triggering portion thereof of  Nippostronglyus brasiliensis  (Nb) and a pharmaceutically acceptable topical carrier or excipient.