Peptide having fibrosis inhibitory activity and composition containing same

Abstract

The present invention relates to a composition for inhibiting fibrosis and more specifically, to a composition for inhibiting fibrosis, wherein the composition is effective in inhibiting fibrosis of tissue cells by containing a peptide derived from telomerase. The peptide according to the present invention exhibits an effect of inhibiting the progression of various kinds of fibrosis, including fibrosis due to occurrence of cancer, fibrosis due to the administration of chemotherapy anticancer drugs, fibrosis due to the exposure to radiation, or progressive fibrosis of tissues, including a TGF-β signaling procedure, and thus can provide a composition for anti-fibrosis or inhibiting fibrosis and a method for treating diseases due to fibrosis.

What is claimed is: 
     
         1 . An anti-fibrosis composition, comprising:
 at least one selected from the group consisting of a peptide comprising an amino acid sequence of SEQ. ID. NO: 1, a peptide having 80% or higher sequence homology with the amino acid sequence, and a fragment thereof.   
     
     
         2 . The anti-fibrosis composition of  claim 1 , wherein the fragment consists of three or more amino acids. 
     
     
         3 . The anti-fibrosis composition of  claim 1 , wherein the fibrosis is induced by at least one selected from the group consisting of cancer, administration of an anticancer agent, and exposure to radiation. 
     
     
         4 . The anti-fibrosis composition of  claim 3 , wherein the composition inhibits fibrosis of tissue of cancer cell selected from the group consisting of pancreatic cancer, colorectal cancer, stomach cancer, prostate cancer, non-small cell lung cancer, breast cancer, melanoma, and ovarian cancer. 
     
     
         5 . The anti-fibrosis composition of  claim 1 , wherein the composition is used in combination with a chemotherapeutic agent or a radiation therapy to inhibit fibrosis of tissue of cancer cell. 
     
     
         6 . The anti-fibrosis composition of  claim 5 , wherein the chemotherapeutic agent is at least one selected from deoxynucleoside analogs and fluoropyrimidines. 
     
     
         7 . The anti-fibrosis composition of  claim 6 , wherein the deoxynucleoside analog is gemcitabine, and the fluoropyrimidine is 5-fluorouracil or capecitabine. 
     
     
         8 . The anti-fibrosis composition of  claim 1 , wherein the composition further comprises pharmaceutically acceptable excipients and additives. 
     
     
         9 . The anti-fibrosis composition of  claim 1 , wherein the composition is involved in a TGF-β signaling process to inhibit fibrosis of dermal tissue. 
     
     
         10 . The anti-fibrosis composition of  claim 9 , wherein the composition further comprises acceptable excipients, lubricants and additives, and is a cosmetic composition. 
     
     
         11 . A method for treating and preventing a fibrotic disease, comprising:
 administering the anti-fibrosis composition according to any one of the  claims 1  to  10  to a subject requiring treatment.   
     
     
         12 . A use for a peptide comprising an amino acid sequence of SEQ. ID. NO: 1, a peptide having 80% or higher sequence homology with the amino acid sequence, or a fragment thereof, as the anti-fibrosis composition according to any one of the  claims 1  to  10 .