Composition for wound treatment containing extract of stellera chamaejasme or fraction thereof and method for treating wound of subject

Abstract

Provided are a composition including Stellera chamaejasme extract for treating wound, a method of treating wound of a subject, a cosmetic composition for wound improving, skin wrinkle improving, or skin anti-aging, and a method of cosmeticizing for wound improving, skin wrinkle improving, or skin anti-aging.

1 . A pharmaceutical composition for treating a wound, comprising a  Stellera chamaejasme  extract or a fraction thereof as an active ingredient, wherein the  Stellera chamaejasme  extract is extracted from an aerial part of  Stellera chamaejasme.    
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the  Stellera chamaejasme  extract is extracted in water, acetone, a C 1 -C 6  alcohol, or a combination thereof. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the  Stellera chamaejasme  extract is extracted in 75% (v/v) to 100% (v/v) ethanol, 75% (v/v) to 100% (v/v) methanol, 75% (v/v) to 100% (v/v) butanol, or a combination thereof. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the fraction is a hexane fraction; an ethyl acetate fraction; a butanol fraction; or a combination thereof, wherein the hexane fraction, the ethyl acetate fraction, and the butanol fraction are obtained by suspending  Stellera chamaejasme  extract in water and then subsequently fractionating a suspension by using hexane, ethyl acetate, and butanol. 
     
     
         5 . The pharmaceutical composition of  claim 1 , wherein the wound is a skin wound. 
     
     
         6 . The pharmaceutical composition of  claim 1 , wherein an amount of the  Stellera chamaejasme  extract or the fraction thereof is in a range of 0.001 percent by weight (wt %) to 80 wt %, based on an amount of the pharmaceutical composition. 
     
     
         7 . The pharmaceutical composition of  claim 1 , further comprising a pharmaceutically acceptable excipient or carrier. 
     
     
         8 . The pharmaceutical composition of  claim 1 , wherein treatment of the wound is by promoting expression of a collagen gene in a cell. 
     
     
         9 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 1  to the subject to treat the wound. 
     
     
         10 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 2  to the subject to treat the wound. 
     
     
         11 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 3  to the subject to treat the wound. 
     
     
         12 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 4  to the subject to treat the wound. 
     
     
         13 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 5  to the subject to treat the wound. 
     
     
         14 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 6  to the subject to treat the wound. 
     
     
         15 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 7  to the subject to treat the wound. 
     
     
         16 . A method of treating a wound of a subject, comprising administering a therapeutically effective amount of the pharmaceutical composition of  claim 8  to the subject to treat the wound.