Stearoyl amino acid salt and method of use thereof

Abstract

An isolated stearoyl amino acid salt of formula (II) or formula (III) is provided, wherein M in the formula (II) is K + , Na + , or NH 4 + ; and M 2+ in the formula (III) is Ba 2+ , Ca 2+ , or Mg 2+ . Also provided are compositions containing the isolated stearoyl amino acid salt and methods of using the isolated stearoyl amino acid salt and composition to treat a disorder, such as cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease.

1 . An isolated stearoyl amino acid salt of formula (II) or formula (III): 
       
         
           
           
               
               
           
         
         wherein M in the formula (II) is K + , Na + , or NH 4   + ; and M 2+  in the formula (III) is Ba 2+ , Ca 2+ , or Mg 2+ . 
       
     
     
         2 . The isolated stearoyl amino acid salt of  claim 1 , being an isolated stearoyl amino acid salt of formula (II), wherein M is K + , Na + , or NH 4   + . 
     
     
         3 . The isolated stearoyl amino acid salt of  claim 1 , being an isolated stearoyl amino acid alt of formula (III), wherein M 2+  is Ba 2+ , Ca 2+ , or Mg 2+ . 
     
     
         4 . An isolated stearoyl amino acid salt of formula (II): 
       
         
           
           
               
               
           
         
         wherein M is K + . 
       
     
     
         5 . An isolated stearoyl amino acid salt of formula (II): 
       
         
           
           
               
               
           
         
         wherein M is Na + . 
       
     
     
         6 . A pharmaceutical composition comprising an effective amount of the isolated stearoyl amino acid salt of  claim 1 , and a pharmaceutically acceptable carrier. 
     
     
         7 . A pharmaceutical composition comprising an effective amount of the isolated stearoyl amino acid salt of  claim 4 , and a pharmaceutically acceptable carrier. 
     
     
         8 . A pharmaceutical composition comprising an effective amount of the isolated stearoyl amino acid salt of  claim 5 , and a pharmaceutically acceptable carrier. 
     
     
         9 . A method of preparing the pharmaceutical composition of  claim 6 , the method comprising combining an effective amount of the isolated stearoyl amino acid salt with a pharmaceutically acceptable carrier. 
     
     
         10 . A method of preparing the pharmaceutical composition of  claim 7 , the method comprising combining an effective amount of the isolated stearoyl amino acid salt with a pharmaceutically acceptable carrier. 
     
     
         11 . A method of preparing the pharmaceutical composition of  claim 8 , the method comprising combining an effective amount of the isolated stearoyl amino acid salt with a pharmaceutically acceptable carrier. 
     
     
         12 . A method of treating a disorder in a subject in need thereof, the method comprising administering to the subject the pharmaceutical composition of  claim 6 , wherein the disorder is selected from the group consisting of cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease. 
     
     
         13 . A method of treating a disorder in a subject in need thereof, the method comprising administering to the subject the pharmaceutical composition of  claim 7 , wherein the disorder is selected from the group consisting of cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease. 
     
     
         14 . A method of treating a disorder in a subject in need thereof, the method comprising administering to the subject the pharmaceutical composition of  claim 8 , wherein the disorder is selected from the group consisting of cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease.