Compositions and Methods for Treating and Removing Seborrheic Keratoses

Abstract

A method of diminishing the appearance of or effecting the removal or disappearance of seborrheic keratoses by the application of compositions containing a) one or more, preferably a combination of, dietary antioxidants and/or antioxidant sources, b) one or more hydrating agents and c) one or more keratolytic agents.

I claim: 
     
         1 . A seborrheic keratosis treatment composition comprising a) one or more, select antioxidants and/or antioxidant sources, b) one or more hydrating agents and c) one or more keratolytic agents wherein the select antioxidants and antioxidant sources are selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, turmeric, hydroxy-1,4-naphthoduinones, catechins, isothiocyantes, carnosol, carnosic acid, ursolic acid, rosmarinic acid, tannins, flavonoids, ellagic acid, allagetannic acid, anthocyartin, β-glurogallin, mucic acid, gallic acid, mucic acid gallates, glycyrrhizinic acid, glycyrrhetinic acid, glabridin, liquirtin, isoliquirtin, α-pinene, 1,8-cineole, camphor, borneaol, ferulic acid, camphene, linalool, d-limonene, apigenin, myrcene, caryopheyllene, lanotstane-type triterpenoids, and boswellic acids. 
     
     
         2 . The composition of  claim 1  wherein the antioxidants and antioxidant sources are selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, turmeric, 5-hydroxy-1,4-naphthoquinone (juglone), 1,4,5-trihydroxynaphthalene, 2,3-dihydro-5-hydroxy-1,4-naphthoquinone, epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC), 4-ethydisulfinyibutyl-isothiocynate, carnosol, carnosis acid, ursolic acid, rosmarinic acid, tannin, ellagic acid, allagetannic acid, anthocyanin, β-glucogallin, mucic acid, gallic acid, mucic acid gallate, mucic acid 1,4-lactone 5-O gallate, mucic acid 1-methyl ester 2-O-gallate, mucic acid 6-O-gallate, glycyrrhizinic acid, glycyrrhetinic acid, glabridin, liquirtin, isoliquirtin, α-pinene, 1,8-cineole, camphor, borneaol, ferulic acid, camphene, linalool, d-limonene, apigenin, myrcene, caryopheyllene, dehyrotumilosic acid, 11-keto-boswellic acid and acetyl-11-keto-boswellic acid. 
     
     
         3 . The composition of  claim 1  wherein at least one antioxidant source is present and is selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, and turmeric. 
     
     
         4 . The composition of  claim 3  wherein at least two antioxidant sources are present. 
     
     
         5 . The composition of  claim 1  wherein the antioxidant source comprises at least three of the following: rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, and turmeric 
     
     
         6 . The composition of  claim 1  wherein the antioxidant source comprises the combination of rosemary essential oil, green tea extract, alma extract and licorice extract, with or without black walnut extract. 
     
     
         7 . The composition of  claim 1  wherein a 1,4 naphthoquinone having the structure I 
       
         
           
           
               
               
           
         
         wherein X is hydrogen, hydroxyl, methyl, methoxy, quartemary amine, ketone, a C 3  to C 7  cycloalkyl, C 2  to C 3  alkyl, 1-alkylaminoalkyl, or alkanoyl group is present. 
       
     
     
         8 . The composition of  claim 7  wherein the 1.4-naphthoquinone is 5-hydroxy-1,4-naphthoquinone or a precursor thereof. 
     
     
         9 . The composition of  claim 8  wherein the precursor is present and is selected from α-hydrojuglone, β-hydrojuglone, 2,3-dihydro-1,4-naphthoquinone and 1,4,5-trihydroxy naphthalene or its glycoside. 
     
     
         10 . The composition of  claim 1  wherein the one or more antioxidants and/or antioxidant sources (a) are present in an amount of from 2 to 40%, the one or more hydrating agents (b) are present in an amount of from 30 to 90% and the one or more keratolytic agents (c) are present in an amount of from 0.5 to 20% by weight based on the combination of (a), (b) and (c). 
     
     
         11 . The composition of  claim 1  further comprising 0.1 to about 80% by weight based on the total weight of the composition of a cosmetically acceptable or pharmaceutically acceptable carrier or excipient. 
     
     
         12 . The composition of  claim 11  further comprising one or more sunscreens, skin lightening actives, vitamins, anti-inflammatory agents, or combinations of two or more of the foregoing. 
     
     
         13 . The composition of  claim 1  present in an effective mount in a cosmetic or skin care product formulation, 
     
     
         14 . A method of ameliorating the manifestation of seborrheic keratosis comprising applying to the surface of the seborrheic keratoses a topical composition comprising an effective amount of an antioxidant or antioxidant source selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, turmeric, hydroxy-1,4-naphthoduinones, catechins, isothiocyantes, carnosol, carnosic acid, ursolic acid, rosmarinic acid, tannins, flavonoids, ellagic acid, allagetannic acid, anthocyanin, β-glucogallin, mucic acid, gallic acid, mucic acid gallates, glycyrrhizinic acid, glycyrrhetinic acid, glabridin, liquirtin, isoliquirtin, α-pinene, 1,8-cineole, camphor, borneaol, ferulic acid, camphene, linalool, d-limonene, apigenin, myrcene, caryopheyllene, lanotstane-type triterpenoids, and boswellic acids. 
     
     
         15 . The method of  claim 14  wherein the antioxidants and antioxidant sources are selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, turmeric, 5-hydroxy-1,4-naphthoquinone (juglone), 1,4,5-trihydroxynaphthalene, 2,3-dihydro-5-hydroxy-1,4-naphthoquinone, epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC), 4-ethydisulfinylbutyl-isothiocynate, carnosol, carnosic acid, ursolic acid, rosmarinic acid, tannin, ellagic acid, allagetannic acid, anthocyanin, β-glucogallin, mucic acid, gallic acid, mucic acid gallate, mucic acid 1,4-lactone 5-O gallate, mucic acid 1-methyl ester 2-O-gallate, mucic acid 6-O-gallate, glycyrrhizinic acid, glycyrrhetinic acid, glabridin, liquirtin isoliquirtin, α-pinene, 1,8-cineole, camphor, borneaol, ferulic acid, camphene, linalool, d-limonene, apigenin, myrcene, caryopheyllene, dehyrotumilosic acid, 11-keto-boswellic acid and acetyl-11-keto-boswellic acid. 
     
     
         16 . The method of  claim 14  wherein at least one antioxidant source is present and is selected from Juglandaceae extracts, black walnut extract, rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, and turmeric. 
     
     
         17 . The method of  claim 16  wherein at least two antioxidant sources are present. 
     
     
         18 . The method of  claim 14  wherein the antioxidant source comprises at least three of the following: rosemary essential oil, green tea extract, pomegranate juice extract, alma extract, licorice extract, licorice white extract, pumelo extract, citrus peel extract, poria extract, boswellia extract, and turmeric 
     
     
         19 . The method of  claim 14  wherein the antioxidant source comprises rosemary essential oil, green tea extract, alma extract and licorice extract, with or without black walnut extract. 
     
     
         20 . The method of  claim 14  wherein a 1,4 naphthoquinone having the structure I 
       
         
           
           
               
               
           
         
         wherein X is hydrogen, hydroxyl, methyl, methoxy, quarternary amine, ketone, a C 3  to C 7  cycloalkyl, C 2  to C 3  alkyl, 1-alkylaminoalkyl, or alkanoyl group is present. 
       
     
     
         21 . The method of  claim 20  wherein the 1,4-naphthoquinone is 5-hydroxy-1,4-naphthoquinone or a precursor thereof. 
     
     
         22 . The method of  claim 21  wherein the precursor is present and is selected from α-hydroluglone, β-hydrojuglone, 2,3-dihydro-1,4-naphthoquinone and 1,4,5-trihydroxy naphthalene or its glycoside. 
     
     
         23 . The method of  claim 14  wherein the antioxidant or antioxidant source is present in an amount of from about 0.001 to about 10% based on the total weight of the composition. 
     
     
         24 . The method of  claim 14  wherein the topical composition further comprises from 0.1 to 99.999% by weight based on the total composition, of a cosmetically acceptable or pharmaceutically acceptable carrier or excipient. 
     
     
         25 . The method of  claim 14  wherein the topical composition comprises from 2 to 40% by weight of the one or more antioxidants and/or antioxidant sources (a) in combination with from 30 to 90%) by weight of one or more hydrating agents (b) and/or from 0.5 to 20% by weight of one or more keratolytic agents (c) based on the total weight of the combination of (a) and (b) and/or (c) wherein the amount of the antioxidants and/or antioxidant sources comprise from 0.1 to 80% by weight based on the total weight of the topical composition.