Potentiation of anticancer agents

Abstract

The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer.

1 . A method for treating a patient having a cancer, said method comprising administering to said patient a pharmaceutical composition comprising:
 (a) a conjugate comprising:
 (i) a polypeptide comprising a sequence at least 80% identical to the amino acid sequence of Angiopep-2, or a biologically active fragment thereof; and 
 (ii) an agent conjugated to said polypeptide; and 
   (b) a solubilizer;   in an amount sufficient to treat said cancer.   
     
     
         2 . The method of  claim 1 , wherein said cancer is a brain cancer. 
     
     
         3 . The method of  claim 2 , wherein said brain cancer is a brain metastasis, a glioblastoma, or a glioma. 
     
     
         4 . The method of  claim 1 , wherein said cancer is outside the brain. 
     
     
         5 . The method of  claim 4 , wherein said cancer is a lung tumor, a breast tumor, a kidney tumor, an eye tumor, a liver tumor, a colorectal tumor, a tumor of an urinary organ, or a metastatic cancer from a breast tumor, a lung tumor, a melanoma, or a brain tumor. 
     
     
         6 . The method of  claim 1 , wherein said cancer includes a cell expressing P-glycoprotein. 
     
     
         7 . The method of  claim 1 , wherein said cancer is multiple drug resistant.