Medications For Deposition On Biological Surfaces

Abstract

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

What is claimed is: 
     
         1 . A personal care composition providing a cool sensation wherein the composition comprises a compound comprising the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         2 . The personal care composition of  claim 1 , wherein the compound activates at least one of TRPA1, TRPV1, or TRPM8. 
     
     
         3 . The personal care composition of  claim 2 , wherein the compound at a concentration of about 0.004% provides greater activation of TRPM8 than WS5 at a concentration of about 30 mM. 
     
     
         4 . The personal care composition of  claim 2 , wherein the compound at a concentration of about 0.02% provides greater activation of TRPA1 than allyl isothiocyanate at a concentration of about 50 mM. 
     
     
         5 . The personal care composition of  claim 2 , wherein the compound at a concentration of about 0.004% provides at least about 110% activation of TRPM8 when compared to WS5 at a concentration of about 30 mM. 
     
     
         6 . The personal care composition of  claim 2 , wherein the compound at a concentration of about 0.02% provides at least about 170% activation of TRPA1 when compared to allyl isothiocyanate at a concentration of about 50 mM. 
     
     
         7 . The personal care composition of  claim 1 , wherein the composition is selected from the group consisting of an oral care composition, a leave-on skin lotion, a shampoo, a body wash, an ointment, a feminine care composition, a baby care composition, and combinations thereof. 
     
     
         8 . The personal care composition of  claim 1  comprising a TRPM8 agonist. 
     
     
         9 . The personal care composition of  claim 1  comprising at least one of a TRPA1 agonist or a TRPV1 agonist.