US2018237531A1PendingUtilityA1

Method for the treatment of pain and osteoarthritis with c-fms antagonists

Assignee: UNIV MELBOURNEPriority: Jul 18, 2011Filed: Apr 17, 2018Published: Aug 23, 2018

Est. expiryJul 18, 2031(~5 yrs left)· nominal 20-yr term from priority

Inventors:Stefan Steidl John Allan Hamilton Andrew David Cook

A61P 43/00A61P 35/00A61P 29/00A61P 25/04A61P 19/02A61K 2039/505C07K 16/244C07K 2317/76C07K 16/243C07K 16/249C07K 16/2866

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Abstract

The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

Claims

exact text as granted — not AI-modified

1 . A method for the treatment of pain or osteoarthritis in a subject, ais method comprising administering to the subject an antagonist of c-Fms, wherein said antagonist is an antibody specific for c-Fms. 
     
     
         2 . The method of  claim 1 , wherein said pain is post-surgical pain. 
     
     
         3 . The method of  claim 1 , wherein said pain is bone cancer pain. 
     
     
         4 . The method of  claim 1 , wherein said pain is rheumatoid arthritic pain. 
     
     
         5 . The method of  claim 1 , wherein said pain is osteoarthritic pain. 
     
     
         6 . The method of  claim 1 , wherein said pain is inflammatory pain. 
     
     
         7 . The method of  claim 1  wherein said subject is a human.

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