System, method and computer readable medium for imaging large areas with microscopic resolution

Abstract

Exemplary systems, method and non-transitory computer-accessible medium can be provided for generating an image of at least one tissue that can be subdivided into a plurality of strips. Using such exemplary systems, method and computer-accessible medium, it is possible to scan, using an optical arrangement to generate first information, a first portion of the tissue(s) along a first one of the strips while the tissue(s) can be mechanically moved in a first direction. Move the one tissue(s), by a distance equal to or less than a width of the first portion, in a second direction approximately perpendicular to the first direction. Use the optical arrangement to generate second information, a second portion of the tissue(s) along a second one of the strips while the tissue(s) can be mechanically moved in a third direction, which can be approximately opposite to the first direction. Then the image can be generated based on the first information and the second information.

What is claims is: 
     
         1 . A non-transitory computer-accessible medium having stored thereon computer-executable instructions for generating an image of at least one tissue which is subdivided into a plurality of strips, wherein, when a computer hardware arrangement executes the instructions, the computer arrangement is configured to perform procedures comprising:
 scanning, using an optical arrangement to generate first information, a first portion of the at least one tissue along a first one of the strips while the at least one tissue is mechanically moved in a first direction;   moving the at least one tissue, by a distance equal to or less than a width of the first portion, in a second direction approximately perpendicular to the first direction;   scanning, using the optical arrangement to generate second information, a second portion of the at least one tissue along a second one of the strips while the at least one tissue is mechanically moved in a third direction, which is approximately opposite to the first direction; and   generating the image of the at least one tissue based on the first information and the second information.   
     
     
         2 . The computer-accessible medium of  claim 1 , wherein the moving procedure is performed without scanning the at least one tissue. 
     
     
         3 . The computer-accessible medium of  claim 1 , wherein the first portion is scanned from a proximal end of the first one of the strips to a distal end thereof. 
     
     
         4 . The computer-accessible medium of  claim 3 , wherein the scanning of the first portion from the proximal end to the distal end of the first one of the strips is performed without stopping. 
     
     
         5 . The computer-accessible medium of  claim 1 , wherein the second portion is scanned from a distal end of the second one of the strips to a proximal end thereof. 
     
     
         6 . The computer-accessible medium of  claim 5 , wherein the scanning of the second portion from the distal end to the proximal end of the first one of the strips is performed without stopping. 
     
     
         7 . The computer-accessible medium of  claim 1 , wherein the scanning of at least one of the first portion or the second portion is performed during a continuous and uninterrupted motion of the at least one tissue. 
     
     
         8 . The computer-accessible medium of  claim 1 , wherein the computer arrangement is further configured to synchronize the scanning of the first portion and the second portion with the moving of the at least one tissue. 
     
     
         9 . The computer-accessible medium of  claim 1 , wherein the first one and the second one of the strips have a square shape. 
     
     
         10 . The computer-accessible medium of  claim 1 , wherein the first one and the second one of the strips have a rectangular shape. 
     
     
         11 . The computer-accessible medium of  claim 10 , wherein each of the rectangularly-shaped first and second ones of the strips has an aspect ratio of approximately 1:25. 
     
     
         12 . The computer-accessible medium of  claim 1 , wherein the image is generated using a moasicing procedure. 
     
     
         13 . The computer-accessible medium of  claim 12 , wherein the mosaicing procedure comprises stitching together images obtained based on the first information and the second information. 
     
     
         14 . A method for generating an image of at least one tissue which is subdivided into a plurality of strips, comprising:
 scanning, using an optical arrangement to generate first information, a first portion of the at least one tissue along a first one of the strips while the at least one tissue is mechanically moved in a first direction;   moving the at least one tissue, by a distance equal to or less than a width of the first portion, in a second direction approximately perpendicular to the first direction;   scanning, using the optical arrangement to generate second information, a second portion of the at least one tissue along a second one of the strips while the at least one tissue is mechanically moved in a third direction, which is approximately opposite to the first direction; and   using a computer hardware arrangement, generating the image of the at least one tissue based on the first information and the second information.   
     
     
         15 . The method of  claim 14 , wherein the moving procedure is performed without scanning the at least one tissue. 
     
     
         16 . The method of  claim 15 , wherein the first portion is scanned from a proximal end of the first one of the strips to a distal end thereof. 
     
     
         17 . The method of  claim 16 , wherein the scanning of the first portion from the proximal end to the distal end of the first one of the strips is performed without stopping. 
     
     
         18 . The method of  claim 15 , wherein the second portion is scanned from a distal end of the second one of the strips to a proximal end thereof. 
     
     
         19 . The method of  claim 18 , wherein the scanning of the second portion from the distal end to the proximal end of the second one of the strips is performed without stopping. 
     
     
         20 . The method of  claim 14 , wherein the scanning of at least one of the first portion or the second portion is performed during a continuous and uninterrupted motion of the at least one tissue. 
     
     
         21 . The method of  claim 14 , synchronizing the scanning of the first portion and the second portion with the moving of the at least one tissue. 
     
     
         22 . The method of  claim 14 , wherein the image is generated using a moasicing procedure. 
     
     
         23 . The method of  claim 22 , wherein the mosaicing procedure comprises stitching together images obtained using the first information and the second information. 
     
     
         24 . A system for generating an image of at least one tissue, comprising:
 an optical scanning arrangement configured to scan a strip of the at least one tissue;   a mechanical arrangement configured to move the at least one tissue when the strip of the at least one tissue is scanned by the optical arrangement; and   an imaging arrangement configured to generate the image based on information received from the optical scanning arrangement.