US2018250246A1PendingUtilityA1

Pain relief compositions, manufacture and uses

Assignee: VIZURI HEALTH SCIENCES LLCPriority: Sep 9, 2011Filed: May 7, 2018Published: Sep 6, 2018
Est. expirySep 9, 2031(~5.1 yrs left)· nominal 20-yr term from priority
A61P 43/00A61P 25/04A61P 31/22A61P 29/00A61P 25/06A61P 1/02A61K 31/196A61K 9/08A61K 31/618A61K 31/351A61K 31/35A61K 45/06A61P 17/06A61K 31/513A61P 11/02A61P 17/04A61K 31/125A61K 31/60A61P 19/02A61K 31/165A61P 15/00A61K 31/045A61K 9/0014A61K 9/06A61P 17/00A61K 47/10A61P 13/10A61K 31/05A61K 31/352A61K 2300/00
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Claims

Abstract

The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.

Claims

exact text as granted — not AI-modified
1 . A composition comprising:
 i) 0.2-30% by weight of a capsaicinoid, and   ii) 50-95% by weight of an analgesic agent comprising a) a topical salicylate and b) a TRPM8 agonist or a TRPV3 agonist, capable of solubilizing said capsaicinoid,   wherein said composition comprises an amount of capsaicinoid sufficient to decrease the density of functional nociceptive nerve fibers when said composition is applied topically to a mammal, and said composition comprises an amount of analgesic agent sufficient to eliminate or reduce the burning or stinging sensation or erythema created by the topical administration of the capsaicinoid to a mammal.

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