US2018258128A1PendingUtilityA1
Antimicrobial compounds, compositions, and uses thereof
Est. expiryMar 10, 2037(~10.7 yrs left)· nominal 20-yr term from priority
A61P 17/00A61P 27/16A61P 13/02C07H 19/10A61P 31/04A61P 15/02A61P 13/10A61P 17/02A61K 31/7076A61K 31/706C07H 19/20C07H 19/052C07H 19/04A61K 31/7068A61P 31/00A61P 13/12A61P 11/00A61K 45/06A61P 3/10A61K 31/7056C07H 19/23C07H 19/02C07F 9/65586A61P 31/10
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Claims
Abstract
Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
Claims
exact text as granted — not AI-modified1 . A compound having the formula:
or a pharmaceutically acceptable salt thereof.
2 . The pharmaceutically acceptable salt of the compound according to claim 1 selected from the group consisting of an ammonium salt, a calcium salt, a sodium salt, a potassium salt, a magnesium salt, and a cobalt salt.
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5 . The pharmaceutically acceptable salt according to claim 2 , wherein the sodium salt is sodium ((2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((butoxyoxidophosphor-yl)oxy)tetrahydrofuran-2-yl)methyl butyl phosphate.
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11 . A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, excipients, or diluents.
12 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition includes at least one additional active ingredient.
13 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is adapted for topical administration.
14 . The pharmaceutical composition of claim 13 , wherein the pharmaceutical composition is administered in the form of a lotion, gel, cream, ointment, oil, solution, suspension, emulsion or other viscous composition.
15 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is adapted for oral administration.
16 . The pharmaceutical composition of claim 15 , wherein the pharmaceutical composition is administered in the form of a capsule, tablet, powder, liquid suspension, solution, elixir, syrup or concentrated drop.
17 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is adapted for inhalation administration.
18 . The pharmaceutical composition of claim 17 , wherein the pharmaceutical composition is administered in the form of a dry powder, solution, suspension or aerosol.
19 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is adapted for intravesical administration.
20 . The pharmaceutical composition of claim 19 , wherein the pharmaceutical composition is administered via a catheter.
21 . The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is adapted for parenteral administration.
22 . The pharmaceutical composition of claim 21 , wherein the pharmaceutical composition is administered via a needle.
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92 . A method of treating an infection in a patient in need thereof, the method comprising administering an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, to the patient.
93 . The method of claim 92 , wherein the infection is an infection of a diabetic foot ulcer.
94 . The method of claim 92 , wherein the infection is a complicated urinary tract infection.
95 . The method of claim 92 , wherein the infection is a lung infection arising from cystic fibrosis.
96 . The method of claim 92 , wherein the infection is an infection in a burn wound.
97 . The method of claim 92 , wherein the infection is a ventilator acquired pneumonia infection.
98 . The method of claim 92 , wherein the infection is an otitis externa infection.
99 . The method of claim 92 , wherein the infection is a bacterial vaginosis infection.
100 . The method of claim 92 , wherein the infection is an impetigo infection.Cited by (0)
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