Compounds, compositions, and methods for the treatment of cancers

Abstract

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.

What is claimed is: 
     
         1 . A compound of Formula I: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, 
         wherein: 
         Y is independently selected from NH and CH 2 ; 
         X is independently selected from acylhydrazone, ester, amide or CH 2    
         n and m are independently selected from 0, 1, 2, 3, 4, 5, and 6; 
         R 1  and R 2  each is Cl, or 
         R 1  and R 2  are joined to form an oxalate; 
         R 3  and R 4  each is NH 3 , or 
         R 3  and R 4  are joined together to form cyclohexane-1,2-diamine and 
         R 5  is alkyl or 
       
       
         
           
           
               
               
           
         
       
     
     
         2 . The compound of  claim 1 , wherein the compound has Formula Ia: 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound of  claim 1 , wherein R 1  and R 2  each is Cl. 
     
     
         4 . The compound of  claim 1 , wherein Y is CH 2 , X is CH 2 , n is 0 and m is 3. 
     
     
         5 . The compound of  claim 1 , wherein Y is NH, X is CH 2 , n is 0 and m is 4. 
     
     
         6 . The compound of  claim 1 , wherein the compound is not 
       
         
           
           
               
               
           
         
       
     
     
         7 . The compound of  claim 1 , wherein R 3  is alkyl. 
     
     
         8 . The compound of  claim 7 , wherein R 3  is methyl. 
     
     
         9 . The compound of  claim 1 , wherein R 3  is 
       
         
           
           
               
               
           
         
       
     
     
         10 . A compound selected from: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         11 . A pharmaceutical composition comprising a compound of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         12 . A method of treating cancer selected from lung cancer, breast cancer, colorectal cancer, ovarian cancer, bladder cancer, prostate cancer, cervical cancer, renal cancer, leukemia, central nervous system cancers, myeloma, and melanoma, comprising administering a therapeutically effective amount of a compound of  claim 1 . 
     
     
         13 . A method of treating cancer selected from lung cancer, breast cancer, colorectal cancer, ovarian cancer, bladder cancer, prostate cancer, cervical cancer, renal cancer, leukemia, central nervous system cancers, myeloma, and melanoma, comprising administering a therapeutically effective amount of a composition of  claim 11 . 
     
     
         14 . A method of inhibiting proliferation of a cell comprising contacting the cell with an effective amount of a compound of  claim 1 . 
     
     
         15 . The method of  claim 14 , wherein the cell is a cancer cell.