Use of an oleogel containing triterpene for healing wounds

Abstract

An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.

What is claimed is: 
     
         1 . A method for enhancing the rate of reepithelialization of a wound, comprising administering to the wound an oleogel comprising a triterpene fraction, wherein the triterpene fraction comprises betulin. 
     
     
         2 . The method of  claim 1 , wherein the triterpene fraction comprises between 1 weight-percent and 20 weight-percent of the oleogel. 
     
     
         3 . The method of  claim 2 , wherein the triterpene fraction comprises between 6 weight-percent and 12 weight-percent of the oleogel. 
     
     
         4 . The method of  claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 60 weight-percent. 
     
     
         5 . The method of  claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 80 weight-percent. 
     
     
         6 . The method of  claim 1 , wherein the triterpene fraction further comprises lupeol. 
     
     
         7 . The method of  claim 6 , wherein the joint fraction of betulin and lupeol in the triterpene fraction is greater than 80 weight-percent in the triterpene fraction. 
     
     
         8 . The method of  claim 1 , wherein the joint fraction of betulin and lupeol in the triterpene fraction is greater than 85 weight-percent in the triterpene fraction. 
     
     
         9 . The method of  claim 1 , wherein the oleogel further comprises a nonpolar liquid. 
     
     
         10 . The method of  claim 9 , wherein the nonpolar liquid is a plant, animal, mineral, or synthetic oil. 
     
     
         11 . The method of  claim 10 , wherein the plant oil is a vegetable oil which is selected from one of the following: sunflower oil, olive oil, avocado oil, and almond oil. 
     
     
         12 . The method of  claim 11 , wherein the nonpolar liquid consists of sunflower oil. 
     
     
         13 . The method of  claim 9 , wherein the nonpolar liquid fraction comprises between 80 weight-percent and 99 weight-percent in relation to the total weight of the oleogel, and wherein the triterpene fraction comprises between 1 weight-percent and 20 weight-percent in relation to the total weight of the oleogel. 
     
     
         14 . The method of  claim 1 , wherein the oleogel further comprises betulinic acid, oleanolic acid, and erythrodiol. 
     
     
         15 . The method of  claim 1 , wherein the method results in complete healing of the wound. 
     
     
         16 . A method for healing a wound caused by a skin disease, comprising administering to the wound an oleogel comprising a triterpene fraction, wherein the triterpene fraction comprises betulin. 
     
     
         17 . A method for healing a wound caused by a therapeutic intervention, comprising administering to the wound an oleogel comprising a triterpene fraction, wherein the triterpene fraction comprises betulin.