Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure

Abstract

A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.

1 . A sheet of biological tissue, the sheet including on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof. 
     
     
         2 . The sheet of biological tissue according to  claim 1 , wherein the sheet of biological tissue is rectangular or substantially rectangular, and includes on a least one side in the length direction tapered edge portion thinning down in the thickness direction, towards the end. 
     
     
         3 . The sheet of biological tissue according to  claim 1 , wherein the angle of the tapered edge is in a range of 10° to 80°. 
     
     
         4 . The sheet of biological tissue according to  claim 1 , wherein the thickness of the sheet is 500 micrometers or less. 
     
     
         5 . The sheet of biological tissue according to  claim 1 , wherein the tapered edge has a slanting shape on one face of the sheet. 
     
     
         6 . The sheet of biological tissue according to  claim 1 , wherein the biological tissue is an animal blood vessel. 
     
     
         7 . The sheet of biological tissue according to  claim 1 , wherein the sheet of biological tissue is decellularized tissue. 
     
     
         8 . A tubular structure, having a tapered portion of the sheet of biological tissue according to  claim 1  positioned on the inner side and fixed to an inner wall of the tubular structure. 
     
     
         9 . A tubular structure, obtained after rolling the sheet into a tubular shape and fixing the tapered portion thereof to the inner wall in such a manner that the tapered portion of the sheet of biological tissue according to  claim 1  is positioned on the inner side and then performing decellularization. 
     
     
         10 . The tubular structure according to  claim 8 , wherein at least a part of a wall portion of the tubular structure has a two-layer structure. 
     
     
         11 . The tubular structure according to  claim 8 , wherein the tapered edge portion is adhered and fixed to the inner wall of the tubular structure. 
     
     
         12 . The tubular structure according to  claim 8 , wherein the inner circumference of the tubular structure is 6.0 millimeters or greater and 40 millimeters or less. 
     
     
         13 . An artificial blood vessel, comprising the tubular structure according to  claim 8 . 
     
     
         14 . A method of using the tubular structure according to  claim 8  as an artificial blood vessel. 
     
     
         15 . Use of the tubular structure according to  claim 8 , to produce an artificial blood vessel.