US2018303777A1PendingUtilityA1

Hyaluronate Compositions

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Assignee: CYPRESS PHARMACEUTICALS INCPriority: Jan 30, 2007Filed: Apr 9, 2018Published: Oct 25, 2018
Est. expiryJan 30, 2027(~0.5 yrs left)· nominal 20-yr term from priority
Inventors:Robert L. Lewis
A61K 31/728A61K 31/7056A61Q 19/007A61K 31/4174A61Q 19/00A61K 45/06A61K 8/735A61P 17/00A61K 9/0014A61K 31/327A61K 31/164A61K 31/522
66
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Claims

Abstract

The present invention provides compositions suitable for topical administration to a mammalian subject including sodium hyaluronate and a pharmaceutically acceptable excipient. The present invention also provides methods for making and using the same.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition suitable for topical administration to a mammalian subject, the composition comprising, by mass, from about 0.05% to about 5% sodium hyaluronate and a pharmaceutically acceptable excipient, wherein from about 0.001 wt % to about 5 wt % of the sodium hyaluronate in the composition has a molecular weight ranging between about 0.01 megadaltons and about 0.4 megadaltons; and wherein the pharmaceutically acceptable excipient is predominantly in the liquid phase at ambient temperature. 
     
     
         2 . The composition of  claim 1 , wherein from about 0.001 wt % to about 5 wt % of the sodium hyaluronate in the composition has a molecular weight ranging between about 0.5 megadaltons and about 1.6 megadaltons. 
     
     
         3 . The composition of  claim 2 , wherein from about 50 wt % to about 95 wt % of the sodium hyaluronate in the composition has a molecular weight ranging between about 1.7 megadaltons and about 4.0 megadaltons. 
     
     
         4 . The composition according to  claim 1 , wherein the pharmaceutically acceptable excipient is selected from the group consisting of water, an alcohol, an oil, glycerin, polyethylene glycol, lanolin, petrolatum, wax, and poloxamer. 
     
     
         5 . The composition according to  claim 4 , wherein the pharmaceutically acceptable excipient is alcohol selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, octyldodecanol, cetostearyl alcohol, and lanolin alcohol. 
     
     
         6 . The composition according to  claim 4 , wherein the pharmaceutically acceptable excipient is oil selected from the group consisting of almond oil, castor oil, corn oil, cottonseed oil, light mineral oil, mineral oil, olive oil, peanut oil, polyoxyl 35 castor oil, sesame oil, soybean oil, and sunflower oil. 
     
     
         7 . The composition according to  claim 4 , wherein the pharmaceutically acceptable excipient is water. 
     
     
         8 . The composition of  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 60% to about 99.9%. 
     
     
         9 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 90.0% to about 99.9%. 
     
     
         10 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 92.5% to about 99.8%. 
     
     
         11 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 95.0% to about 99.7%. 
     
     
         12 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 97.5% to about 99.6%. 
     
     
         13 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 98.5% to about 99.5%. 
     
     
         14 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 99.0% to about 99.4%. 
     
     
         15 . The composition according to  claim 7 , wherein the ratio of the mass of water to the total mass of the composition ranges from about 99.2% to about 99.3%. 
     
     
         16 . The composition according to  claim 5 , wherein the ratio of the mass of water to the total mass of the composition is about 99.235%. 
     
     
         17 . The composition of  claim 1 , wherein the composition further comprises an antifungal agent. 
     
     
         18 . The composition according to  claim 17 , wherein the antifungal agent is selected from the group consisting of clioquinol, haloprogin, miconazole nitrate, povidone-iodine, tolnaftate, ketoconazole, undecylenic acid, butoconazole and clotrimazole. 
     
     
         19 . The composition according to  claim 18 , wherein the antifungal agent is clotrimazole. 
     
     
         20 . The composition according to  claim 1 , wherein the composition further comprises an antibiotic.

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