Acute Respiratory Distress Syndrome Therapeutic Agent

Abstract

An agent for treating acute respiratory distress syndrome includes, as an active ingredient, a lecithinized superoxide dismutase represented by the general formula (I): SOD′(Q-B) m   (I) (wherein, SOD′ represents a residue of a superoxide dismutase; Q represents a chemical crosslinking; B represents a residue of lysolecithin, in which a hydrogen atom of a hydroxyl group is removed from the lysolecithin having the hydroxyl group at the 2-position of glycerol; and m is the average number of bonds of the lysolecithin relative to one molecule of the superoxide dismutase and represents an integer of 1 or more).

1 . An agent for treating acute respiratory distress syndrome comprising, as an active ingredient, a lecithinized superoxide dismutase represented by the following general formula (I):
   SOD′(Q-B) m   (I)
   wherein, SOD′ represents a residue of a superoxide dismutase; Q represents a chemical crosslinking; B represents a residue of lysolecithin, in which a hydrogen atom of a hydroxyl group is removed from the lysolecithin having the hydroxyl group at the 2-position of glycerol; and m is the average number of bonds of the lysolecithin relative to one molecule of the superoxide dismutase and represents an integer of 1 or more.   
     
     
         2 . The agent for treating acute respiratory distress syndrome according to  claim 1 , wherein Q in the general formula (I) is —C(O)—(CH 2 ) n —C(O)—, wherein, n represents an integer of 2 or more. 
     
     
         3 . The agent for treating acute respiratory distress syndrome according to  claim 1 , wherein SOD′ is a residue of a human superoxide dismutase. 
     
     
         4 . The agent for treating acute respiratory distress syndrome according to  claim 1 , wherein SOD′ is a residue of a modified superoxide dismutase in which an amino acid at a 111-position in an amino acid sequence of a human superoxide dismutase is converted into S-(2-hydroxyethylthio)cysteine. 
     
     
         5 . The agent for treating acute respiratory distress syndrome according to  claim 3 , wherein the superoxide dismutase is a superoxide dismutase containing copper and zinc in an active center thereof. 
     
     
         6 . The agent for treating acute respiratory distress syndrome according to  claim 2 , wherein n is an integer of 2 to 10. 
     
     
         7 . The agent for treating acute respiratory distress syndrome according to  claim 1 , wherein m is an integer of 1 to 12. 
     
     
         8 . The agent for treating acute respiratory distress syndrome according to  claim 1 , further comprising a stabilizing agent. 
     
     
         9 . The agent for treating acute respiratory distress syndrome according to  claim 8 , wherein the stabilizing agent is a sugar. 
     
     
         10 . The agent for treating acute respiratory distress syndrome according to  claim 9 , wherein the sugar is sucrose. 
     
     
         11 . The agent for treating acute respiratory distress syndrome according to  claim 10 , wherein the sucrose is sucrose treated with activated carbon.