Novel compounds

Abstract

and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

1 - 12 . (canceled) 
     
     
         13 . A compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein 
         R 1  is 9- or 10-membered bicyclic heteroaryl wherein the 9- or 10-membered bicyclic heteroaryl contains from one to three heteroatoms independently selected from oxygen and nitrogen and is optionally substituted by C 1-6 alkyl, C 3-6 cycloalkyl, halo, —CN or —NHSO 2 R 5 , or 
         pyridinyl optionally substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 6 , halo and —NHSO 2 R 7 ; 
         R 2  and R 3 , together with the nitrogen atom to which they are attached, are linked to form a 6- or 7-membered heterocyclyl wherein the 6- or 7-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom; 
         R 4  is hydrogen or methyl; 
         R 6  is hydrogen or C 1-4 alkyl; and 
         R 5  and R 7  are each independently C 1-6 alkyl, or phenyl optionally substituted by one or two substituents independently selected from halo; 
         or a salt thereof. 
       
     
     
         14 . The compound according to  claim 13 , wherein R 1  is
 9-membered bicyclic heteroaryl wherein the 9-membered bicyclic heteroaryl contains one or two nitrogen atoms, or pyridinyl optionally substituted by one or two substituents independently selected from —OR 6  and —NHSO 2 R 7 .   
     
     
         15 . A compound according to  claim 13 , wherein R 1  is indolyl. 
     
     
         16 . A compound according to  claim 13 , wherein R 1  is pyridinyl optionally substituted by one or two substituents independently selected from —OR 6  and —NHSO 2 R 7 . 
     
     
         17 . A compound according to  claim 13 , wherein R 2  and R 3 ,
 together with the nitrogen atom to which they are attached, are linked to form a 6-membered heterocyclyl wherein the 6-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom.   
     
     
         18 . A compound according to  claim 13 , wherein R 2  and R 3 , together with the nitrogen atom to which they are attached, are linked to form a 6-membered heterocyclyl wherein the 6-membered heterocyclyl contains an oxygen atom. 
     
     
         19 . A compound according to  claim 13 , wherein R 2  and R 3 , together with the nitrogen atom to which they are attached, are linked to form a 6-membered heterocyclyl wherein the 6-membered heterocyclyl contains a further nitrogen atom. 
     
     
         20 . A compound according to  claim 13 , wherein R 4  is hydrogen. 
     
     
         21 . A compound according to  claim 13  wherein the compound of formula (I) is in the form of a pharmaceutically acceptable salt thereof.