Immobilised biological entities

Abstract

There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.

1 - 38 . (canceled) 
     
     
         39 . A heparin moiety capable of interacting with mammalian blood to prevent coagulation or thrombus formation which entity carries an alkyne or an azido group, which alkyne or azido group is attached to a linker, wherein the linker is end-point attached to the heparin moiety. 
     
     
         40 . A heparin moiety according to claim  38  which is a full length heparin. 
     
     
         41 . A heparin moiety according to claim  38  wherein the heparin moiety is covalently end-point attached through position C1 of the reducing terminal to the linker.