Drug infusion system and method for controlling blood pressure

Abstract

Various embodiments relating to a method of controlling the blood pressure of a subject is provided, the method includes generating blood pressure data indicating the blood pressure of the subject, controlling a plurality of pumps to infuse, in dependence on the blood pressure data, drugs into the subject, wherein each of the plurality of pumps is adapted to infuse one out of a plurality of different drugs into the subject, and wherein each of the plurality of different drugs has a particular influence on the blood pressure of the subject, wherein the plurality of pumps is controlled such that, in dependence on the blood pressure data, a mix of drugs is infused into the subject which stabilizes the blood pressure of the subject.

1 . A method of controlling a blood pressure of a subject, comprising:
 calibrating a blood pressure baseline for the subject;   selecting a blood pressure threshold corresponding to said blood pressure baseline;   calibrating a heart rate baseline for the subject;   selecting a heart rate threshold corresponding to said heart rate baseline;   calculating a final mean blood pressure indicating the blood pressure of the subject during a pre-determined period, wherein the blood pressure is generated by a non-invasive blood pressure data generating unit   such that, calculating the final mean blood pressure includes the step of applying a greater weight to blood pressure measured in a later part of the pre-determined period than during an earlier part;   generating heart rate data indicating a heart rate of the subject;   controlling a plurality of pumps to infuse drugs into the subject, wherein each of the plurality of pumps is adapted to infuse one out of a plurality of different drugs into the subject, and wherein each of the plurality of different drugs has a particular influence on the blood pressure of the subject;   wherein the plurality of pumps is controlled such that, in dependence on the final mean blood pressure relative to the blood pressure threshold and the heart rate data relative to the heart rate threshold, a mix of drugs is infused into the subject which stabilizes the blood pressure of the subject, wherein the plurality of pumps is controlled to infuse drugs into the subject if the blood pressure of the subject falls below the blood pressure threshold, wherein the injection of drugs into the subject is continued in regular time intervals ranging between 15 and 30 seconds until the blood pressure exceeds the blood pressure threshold.   
     
     
         2 . The method according to  claim 1 , wherein the blood pressure threshold is below 90% of a baseline blood pressure. 
     
     
         3 . The method according to  claim 1 , wherein a first pump of the plurality of pumps is controlled to infuse a first drug into the subject if the heart rate of the subject exceeds the heart rate threshold. 
     
     
         4 . The method according to  claim 1 , wherein a second pump of the plurality of pumps is controlled to infuse a second drug into the subject if the heart rate of the subject falls below the heart rate threshold. 
     
     
         5 . The method according to  claim 1 , wherein the heart rate threshold is below 60 beats per minute. 
     
     
         6 . The method according to  claim 3 , wherein the first drug is Phenylephrine. 
     
     
         7 . The method according to  claim 4 , wherein the second drug is Ephedrine. 
     
     
         8 . The method according to  claim 6 , wherein Phenylephrine is injected with a dose of between about 0.01 mg to 0.2 mg or 0.025 mg at regular time intervals. 
     
     
         9 . The method according to  claim 7 , wherein Ephedrine is injected with a dose of between about 0.5 mg to 4 mg or 2 mg at regular time intervals. 
     
     
         10 . The method according to  claim 1 , wherein the blood pressure data and/or heart rate data is collected in real time. 
     
     
         11 . A system of controlling a blood pressure of a subject, comprising:
 a blood pressure data generating unit adapted to generate blood pressure data indicating the blood pressure of the subject, and further adapted to calibrate a blood pressure baseline for the subject and select a blood pressure threshold corresponding to said blood pressure baseline;   said blood pressure data generating unit adapted to calculate a mean final blood pressure indicating the blood pressure of the subject during a pre-determined period, such that, the final mean blood pressure includes a greater weight to blood pressure measured in a later part of the pre-determined period than during an earlier part;   wherein the blood pressure is generated by a non-invasive blood pressure data generating unit;   wherein blood pressure data generating unit is non-invasive;   a heart rate data generating unit adapted to generate heart rate data indicating a heart rate of the subject, and further adapted to calibrate a heart rate baseline for the subject and select a heart rate threshold corresponding to said heart rate baseline;   a plurality of pumps, wherein each of the plurality of pumps is adapted to infuse one out of a plurality of different drugs into the subject, each of the plurality of different drugs having a particular influence on the blood pressure of the subject,   a controlling unit adapted to control the plurality of pumps to infuse, in dependence on the final mean blood pressure relative to the blood pressure threshold and the heart rate data relative to the heart rate threshold, a mix of drugs into the subject which stabilizes the blood pressure of the subject, wherein the plurality of pumps are controlled such that drugs are infused into the subject if the blood pressure of the subject falls below the blood pressure threshold, wherein the controlling unit is adapted to cause the injection of drugs into the subject in regular time intervals ranging between 15 and 30 seconds until the blood pressure exceeds the blood pressure threshold.   
     
     
         12 . The system according to  claim 11 , wherein the blood pressure threshold falls below 90% of a baseline blood pressure. 
     
     
         13 . The system according to  claim 11 , wherein the controlling unit is adapted to control a first pump of the plurality of pumps to infuse a first drug into the subject if the heart rate of the subject exceeds the heart rate threshold. 
     
     
         14 . The system according to  claim 11 , wherein the controlling unit is adapted to control a second pump of the plurality of pumps to infuse a second drug into the subject if the heart rate of the subject falls below the heart rate threshold. 
     
     
         15 . The system according to  claim 11 , wherein the heart rate threshold falls below 60 beats per minute. 
     
     
         16 . The system according to  claim 13 , wherein the first drug is Phenylephrine. 
     
     
         17 . The system according to  claim 14 , wherein the second drug is Ephedrine. 
     
     
         18 . The system according to  claim 16 , wherein the controlling unit is adapted to cause injection of Phenylephrine with a dose of between about 0.01 mg to 0.2 mg or 0.025 mg mg at regular time intervals. 
     
     
         19 . The system according to  claim 17 , wherein the controlling unit is adapted to cause injection of Ephedrine with a dose of between about 0.5 mg to 4 mg or 2 mg at regular time intervals.