BINDING MEMBERS OF INTERLEUKIN-4 RECEPTOR ALPHA (IL4-Ra)

Abstract

Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 and/or IL-13, examples of which are asthma and COPD.

1 . An isolated antibody or fragment thereof that specifically binds an epitope on human interleukin-4 receptor alpha (hIL-4Rα), wherein the epitope comprises L67 and L68 of loop 2 and D92 and V93 of loop 3 according to SEQ ID NO: 460. 
     
     
         2 . The isolated antibody or fragment of  claim 1 , wherein the epitope comprises amino acid residues within V65-H72 of loop 2 and L89-N98 of loop 3 according to SEQ ID NO: 460 or a portion thereof. 
     
     
         3 . The isolated antibody or fragment of  claim 1 , wherein the antibody molecule is an IgG1, IgG2 or IgG4 molecule. 
     
     
         4 . An isolated antibody or fragment thereof that specifically binds to an epitope on human interleukin-4 receptor alpha (hIL-4Rα), wherein the epitope comprises amino acid residues V65-H72 and L89-N98 of SEQ ID NO: 460. 
     
     
         5 . The isolated antibody or fragment of  claim 4 , wherein the isolated antibody or fragment thereof cross-reacts with cynomolgous monkey IL-4Rα. 
     
     
         6 . The isolated antibody or fragment of  claim 4 , wherein the isolated antibody is an IgG1, IgG2 or IgG4 molecule.