Use of enzyme-modified isoquercitrin

Abstract

The present invention provides a salivator that is in a form for use in the mouth (a form for intraoral use), or in a form for use by oral administration (a form for oral administration). The salivator can be prepared by using enzymatically modified isoquercitrin, or a combination of enzyme-modified isoquercitrin and a thickening polysaccharide. The present invention further provides an additive that is useful for preparing an oral composition (a food or beverage, a pharmaceutical product for oral administration)(an additive for an oral composition) and that can impart at least one effect selected from the group consisting of a salivation-promoting effect, a deglutition-improving effect (swallowing-assisting effect), and a mastication-improving effect (chewing-assisting effect) to the oral composition. The additive can be prepared by using a combination of enzymatically modified isoquercitrin and a thickening polysaccharide.

1 . An additive for a composition for intraoral use or oral intake comprising enzymatically modified isoquercitrin and a polysaccharide for thickening. 
     
     
         2 . The additive for a composition for intraoral use or oral intake according to  claim 1 , wherein the polysaccharide for thickening is at least one member selected from the group consisting of xanthan gum, locust bean gum, guar gum, tara gum, deacylated gellan gum, native gellan gum, pectin, alginic acid salts, gelatin, agar, psyllium seed gum, and carrageenan. 
     
     
         3 . The additive for a composition for intraoral use or oral intake according to  claim 1 , which comprises the polysaccharide for thickening in a proportion of 0.2 to 500 parts by mass per part by mass of the enzymatically modified isoquercitrin. 
     
     
         4 . The additive for a composition for intraoral use or oral intake according to  claim 1 , wherein the composition for intraoral use or oral intake is a food or beverage, or a pharmaceutical product. 
     
     
         5 . The additive for a composition for intraoral use or oral intake according to  claim 1 , wherein the composition for intraoral use or oral intake is a food or beverage or a pharmaceutical product that is ingested by or administered to at least one person selected from the group consisting of persons with reduced salivation function, persons with reduced swallowing function, and persons with reduced chewing function. 
     
     
         6 . The additive for a composition for intraoral use or oral intake according to  claim 1 , which is an additive for preparing a composition for intraoral use or oral intake in the form of a gel having at least one of the following physical properties (1) and (2), or in the form of a sol having the following physical property (3):
 (1) breaking strain: 0.3 to 0.8;   (2) hardness: 500 to 500,000 N/m 2 ; and   (3) viscosity (shear rate: 100[S −1 ]): 0.006 to 0.6 Pa·s.   
     
     
         7 . A composition for intraoral use or oral intake, comprising the additive for a composition for intraoral use or oral intake according to  claim 1 . 
     
     
         8 . The composition for intraoral use or oral intake according to  claim 7 , which is a food or beverage or a pharmaceutical product that is ingested by or administered to at least one person selected from the group consisting of persons with reduced salivation function, persons with reduced swallowing function, and persons with reduced chewing function. 
     
     
         9 . The composition for intraoral use or oral intake according to  claim 7 , which is a food or beverage or a pharmaceutical product in the form of a gel having at least one of the following physical properties (1) and (2), or in the form of a sol having the following physical property (3):
 (1) breaking strain: 0.3 to 0.8;   (2) hardness: 500 to 500,000 N/m 2 ; and   (3) viscosity (shear rate: 100[S −1 ]): 0.006 to 0.6 Pa·s.   
     
     
         10 . A method for preparing a composition for intraoral use or oral intake, comprising the additive for a composition for intraoral use or oral intake according to  claim 1 , said method comprising the step of incorporating enzymatically modified isoquercitrin and a polysaccharide for thickening, or the additive for a composition for intraoral use or oral intake according to  claim 1  into a food or beverage or a pharmaceutical product having a water content of 60 mass % or more. 
     
     
         11 . A salivator comprising enzymatically modified isoquercitrin as an active ingredient, or enzymatically modified isoquercitrin and a polysaccharide for thickening as active ingredients. 
     
     
         12 . The salivator according to  claim 11 , which is in the form of a composition for intraoral use or oral intake. 
     
     
         13 . The salivator according to  claim 11 , which is in the form of a syrup, health drink, liquid, emulsion, oil, spray, gel, paste, tablet, chewable agent, lozenge, pill, granule, powder, dry syrup, film, or stick-shaped preparation. 
     
     
         14 . (canceled) 
     
     
         15 . (canceled) 
     
     
         16 . A composition for intraoral use or oral intake, comprising the additive for a composition for intraoral use or oral intake according to  claim 6 . 
     
     
         17 . The composition for intraoral use or oral intake according to  claim 16 , which is a food or beverage or a pharmaceutical product that is ingested by or administered to at least one person selected from the group consisting of persons with reduced salivation function, persons with reduced swallowing function, and persons with reduced chewing function. 
     
     
         18 . The composition for intraoral use or oral intake according to  claim 17 , which is a food or beverage or a pharmaceutical product in the form of a gel having at least one of the following physical properties (1) and (2), or in the form of a sol having the following physical property (3):
 (1) breaking strain: 0.3 to 0.8;   (2) hardness: 500 to 500,000 N/m 2 ; and   (3) viscosity (shear rate: 100[S −1 ]): 0.006 to 0.6 Pa·s.   
     
     
         19 . A method for preparing a composition for intraoral use or oral intake, comprising the additive for a composition for intraoral use or oral intake according to  claim 6 , said method comprising the step of incorporating enzymatically modified isoquercitrin and a polysaccharide for thickening, or the additive for a composition for intraoral use or oral intake according to  claim 6  into a food or beverage or a pharmaceutical product having a water content of 60 mass % or more.