US2018346431A1PendingUtilityA1
Treatment of cancer/inhibition of metastasis
Est. expiryOct 13, 2030(~4.2 yrs left)· nominal 20-yr term from priority
Inventors:Mustafa Bilgin Ali Djamgoz
A61P 43/00A61P 13/08A61P 15/00A61P 35/04A61K 31/428A61K 31/495A61K 31/00A61K 31/4458C07D 277/82A61K 31/167A61K 31/19C07D 241/04C07D 295/15A61K 31/138
52
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
Claims
exact text as granted — not AI-modified1 - 16 . (canceled)
17 . A method of reducing or preventing metastatic behaviour in VGSC expressing cancer, comprising administering riluzole without directly killing the cancer cells.
18 . A method according to claim 17 , wherein the cancer is breast cancer.
19 . A method according to claim 17 , wherein the cancer is prostate cancer.
20 . A method of reducing or preventing metastatic behaviour in VGSC expressing cancer by administering a drug having the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part.
21 . A method according to claim 20 , wherein the cancer is breast cancer.
22 . A method according to claim 20 , wherein the cancer is prostate cancer.
23 - 26 . (canceled)Join the waitlist — get patent alerts
Track US2018346431A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.