Modulators of 5-ht receptors and methods of use thereof

Abstract

The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , A, Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

1 . A compound of formula (I): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or prodrug thereof, wherein
 A is selected from the group consisting of 
 
       
         
           
           
               
               
           
         
         R 1 , R 3 , R 4 , and R 5  are independently selected from the group consisting of hydrogen, alkenyl, alkyl, haloalkyl, G 1 , G 2 , —(CR 4a R 5a ) m -G 1 , and —(CR 4a R 5a ) m -G 2 ;
 R 4a  and R 5a , at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl; 
 G 1 , at each occurrence, is independently aryl or heteroaryl, wherein each G 1  is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, —NO 2 , —OR 1b , —OC(O)R 1b , —OC(O)N(R b )(R 3b ), —SR 1b , —S(O)R 2b , —S(O) 2 R 2b , —S(O) 2 N(R b )(R 3b ), —C(O)R 1b , —C(O)OR 1b , —C(O)N(R b )(R 3b ), —N(R b )(R 3b ), —N(R a )C(O)R 1b , —N(R a )C(O)O(R 1b ), —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —NO 2 , —N(R b )S(O) 2 (R 2b ), —(CR 4b R 5b ) m —OR 1b , —C(OH)[(CR 4b R 5b ) m —R 4b ] 2 , —(CR 4b R 5b ) m —OC(O)R 1b , —(CR 4b R 5b ) m —OC(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —SR 1b , —(CR 4b R 5b ) m —S(O)R 2b , —(CR 4b R 5b ) m —S(O) 2 R 2b , —(CR 4b R 5b ) m —S(O) 2 N(R b )(R 3b ), —(CR 4b R 5b ) m —C(O)R 1b —(CR 4b R 5b ) m —C(O)OR 1b , —(CR 4b R 5b ) m —C(O)N(R 3b ), —(CR 4b R 5b ) m —N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R a )C(O)R 1b , —(CR 4b R 5b ) m —N(R a )C(O)O(R 1b ), —(CR 4b R 5b ) m —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )S(O) 2 (R 2b ), cyanoalkyl, and haloalkyl; 
 G 2  is cycloalkyl, cycloalkenyl, or heterocycle unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, oxo, —SR 1b , —S(O)R 2b , —S(O) 2 R 2b , —S(O) 2 N(R b )(R 3b ), —C(O)R 1b , —C(O)OR 1b , —C(O)N(R b )(R 3b ), —N(R b )(R 3b ), —N(R a )C(O)R 1b , —N(R a )C(O)O(R 1b ), —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —NO 2 , —N(R b )S(O) 2 (R 2b ), —(CR 4b R 5b ) m —OR 1b , —(CR 4b R 5b ) m —OC(O)R 1b , —(CR 4b R 5b ) m —OC(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —SR 1b , —(CR 4b R 5b ) m —S(O)R 2b , —(CR 4b R 5b ) m —S(O) 2 R 2b , —(CR 4b R 5b ) m —S(O) 2 N(R b )(R 3b ), —(CR 4b R 5b ) m —C(O)R 1b , —(CR 4b R 5b ) m —C(O)OR 1b , —(CR 4b R 5b ) m —C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R a )C(O)R 1b , —(CR 4b R 5b ) m —N(R a )C(O)O(R 1b ), —(CR 4b R 5b ) m —N(R a )C(O)N(R b )(R 3b ), —(CR 4b R 5b ) m —N(R b )S(O) 2 (R 2b ), cyanoalkyl, and haloalkyl; 
 R a  and R b , at each occurrence, are each independently hydrogen, alkyl, or haloalkyl; 
 R 1b  and R 3b , at each occurrence, are each independently hydrogen, alkyl, or haloalkyl; 
 R 2b , at each occurrence, is independently alkyl or haloalkyl; 
 R 4b  and R 5b , at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl; 
 m, at each occurrence, is independently 1, 2, 3, 4, or 5; 
 
         R 2  is selected from the group consisting of hydrogen, alkoxyalkyl, alkyl, alkylcarbonyl, haloalkyl, —(CR 4a R 5a ) m -G 1 , —(CR 4a R 5a ) p —O-G 1 , —C(O)-G 1 , —(CR 4a R 5a ) m -G 2 , —(CR 4a R 5a ) p —O-G 2 , —C(O)-G 2 , —S(O) 2 R 6 , and —C(O)NR 7 R 8 ;
 p, at each occurrence, is independently 2, 3, 4, or 5; 
 
         R 6  and R 7  are independently selected from the group consisting of alkyl, haloalkyl, G 1 , —(CR 4a R 5a ) m -G 1 , G 2  and —(CR 4a R 5a ) m -G 2 ; 
         R 8  is selected from the group consisting of hydrogen, alkyl, and haloalkyl; or 
         R 7  and R 8  taken together with the nitrogen to which they are attached form a heterocycle; 
         X 1  is N or CR 9 ; 
         X 2  is N or CR 10 ; 
         X 3  is N or CR 11 ; 
         X 4  is N or CR 12 ; 
         provided that only one or two of X 1 , X 2 , X 3 , or X 4  can be N; 
         R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15  and R 16  are each independently hydrogen, alkyl, alkenyl, alkynyl, halogen, cyano, -G 1 , -G 2 , —NO 2 , —OR 1a , —OC(O)R 1a , —OC(O)N(R b )(R 3a ), —SR 1a , —S(O)R 2a , —S(O) 2 R 2a , —S(O) 2 N(R b )(R 3a ), —C(O)R 1a , —C(O)G 3 , —C(O)OR 1a , C(O)N(R b )(R 3a ), —N(R b )(R 3a ), —N(R a )C(O)R 1a , —N(R a )C(O)O(R a ), —N(R a )C(O)N(R b )(R 3a ), —N(R a )S(0) 2 (R 2a ), —(CR 4a R 5a ) m —NO 2 —(CR 4a R 5a ) m —OR 1a , —(CR 4a R 5a ) m —OC(O)R 1a , —(CR 4a R 5a ) m —OC(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —SR 1a , —(CR 4a R 5a ) m —S(O)R 2a , —(CR 4a R 5a ) m —S(O) 2 R 2a , —(CR 4a R 5a ) m —C(O)R 1a , —(CR 4a R 5a ) m —C(O)OR 1a , —(CR 4a R 5a ) m —C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R a ) C(O)R 1a , —(CR 4a R 5a ) m —N(R a )C(O)O(R 1a ), —(CR 4a R 5a ) m —N(R a )C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m -G 1 , —CR 4a ═CR 5a -G 1 , —(CR 4a R 5a ) m -G 2 , —CR 4a ═CR 5a -G 2 , —CR 6a ═C(R 7a ) 2 , cyanoalkyl, haloalkyl, (v), (vi), (vii) or (vi); wherein 
       
       
         
           
           
               
               
           
         
         
           R 1a  and R 3a , at each occurrence, are each independently hydrogen, alkyl, haloalkyl, G 1 , —(CR 4a R 5a ) m -G 1 , G 2 , or —(CR 4a R 5a ) m -G 2 ; 
           R 2a , at each occurrence, is independently alkyl, haloalkyl, G 1 , or —(CR 4a R 5a ) m -G 1 ; 
           R 6a  is alkyl or haloalkyl; 
           R 7a , at each occurrence, is independently hydrogen, alkyl, or haloalkyl; 
           G 3  is a heterocyclic ring attached to the adjacent carbonyl moiety through a nitrogen atom contained within the heterocycle; 
           q is 1 or 2; 
         
         R 9  and R 10 , R 10  and R 11 , R 11  and R 12 , or R 13  and R 14  taken together with the carbon atoms to which they are attached form a substituted or unsubstituted phenyl, cycloalkyl, heterocycle, or heteroaryl ring; 
         Y 1  is NR 17 , CR 18 R 19 , C(O), S(O) n , or O; 
         Y 2  is NR 20 , CR 18 R 19 , C(O), or S(O) n ; 
         Y 3  is NR 17 , CR 18 R 19 ; C(O), or S(O) n ; or 
         Y 1  and Y 2  together are CR 18 =R 19 , provided that Y 3  is other than NR 17 ; or 
         Y 2  and Y 3  together are CR 18 =R 19 , provided that Y 1  is other than NR 17  or O;
 n is 1 or 2; 
 provided that only one of Y 1  and Y 3  can be NR 17 ; or Y 1  and Y 3  are other than NR 17  when Y 2  is NR 20 ; or only one of Y 1 , Y 2 , or Y 3  can be C(O) or S(O) n ; or Y 2  is other than NR 20  or S(O) n  when Y 1  is O; or Y 3  is other than NR 17  when Y 1  is O; 
 
         R 17  is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, haloalkyl, —C(O)-G 1 , —(CR 4a R 5a ) m -G 1 , —C(O)-G 2 , and —(CR 4a R 5a ) m -G 2 ; 
         R 18  and R 19  are independently selected from the group consisting of hydrogen, alkyl, and haloalkyl; and 
         R 20  is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, haloalkyl, —C(O)-G 1 , —C(O)NR a -G 1 , —S(O) n -G 1 , —(CR 4a R 5a ) m -G 1 , —C(O)-G 2 , —C(O)NR a -G 2 , —S(O) n -G 2 , and —(CR 4a R 5a ) m -G 2 . 
       
     
     
         2 . The compound of  claim 1 , wherein A is (i) 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound of  claim 1 , wherein A is (ii), (iii), or (iv) 
       
         
           
           
               
               
           
         
       
     
     
         4 . (canceled) 
     
     
         5 . The compound of  claim 1 , wherein Y 1  is CR 18 R 19 , Y 2  is NR 20 , and Y 3  is C(O), or wherein Y 1  is CR 18 R 19 , Y 2  is C(O), and Y 3  is NR 20 . 
     
     
         6 .- 11 . (canceled) 
     
     
         12 . The compound of  claim 1 , wherein R 2  is selected from the group consisting of hydrogen, alkyl, haloalkyl, —(CR 4a R 5a ) m -G 1 , or —S(O) 2 R 6 . 
     
     
         13 . The compound of  claim 2 , wherein R 9 , R 10 , R 11 , and R 12  are each hydrogen, or wherein one or two of R 9 , R 10 , R 11 , and R 12  are each independently alkyl, alkenyl, alkynyl, halogen, cyano, -G 1 , -G 2 , —NO 2 , —OR 1a , —OC(O)R 1a , —OC(O)N(R b )(R 3a ), —SR 1a , —S(O)R 2a , —S(O) 2 R 2a , —S(O) 2 N(R b )(R 3a ), —C(O)R 1a , —C(O)G 3 , —C(O)OR 1a , —C(O)N(R b )(R 3a ), —N(R b )(R 3a ), —N(R a )C(O)R 1a , —N(R a )C(O)O(R 1a ), —N(R a )C(O)N(R b )(R 3a ), —N(R a )S(O) 2 (R 2a ), —(CR 4a R 5a ) m —NO 2 , —(CR 4a R 5a ) m —OR 1a , —(CR 4a R 5a ) m —OC(O)R 1a , —(CR 4a R 5a ) m —OC(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —SR 1a , —(CR 4a R 5a ) m —S(O)R 2a , —(CR 4a R 5a ) m —S(O) 2 R 2a , —(CR 4a R 5a ) m —S(O) 2 N(R b )(R b )(R 3a ), (CR 4a R 5a ) m —C(O)R 1a , —(CR 4a R 5a ) m —C(O)OR 1a , —(CR 4a R 5a ) m —C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R b )(R 3a ), —(CR 4a R 5a ) m —N(R a )C(O)R 1a , —(CR 4a R 5a ) m —N(R a )C(O)O(R 1a ), —(CR 4a R 5a )N(R a )C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m -G 1 , —CR 4a ═CRsa-G 1 , —(CR 4a R 5a ) m -G 2 , CR 4a ═CR 5a -G 2 , cyanoalkyl, haloalkyl, (v), (vi), (vii) or (viii), 
       
         
           
           
               
               
           
         
       
       and R 9 , R 10 , R 11 , and R 12  are hydrogen. 
     
     
         14 . The compound of  claim 3 , wherein R 13 , R 14 , R 15  and R 16  are each independently hydrogen, alkyl, halogen, cyano, -G 1 , -G 2 , —NO 2 , —OR 1a , —S(O) 2 R 2a , —S(O) 2 N(R b )(R 3a ), —C(O)R 1a , —C(O)OR 1a , —C(O)N(R b )(R 3a ), —(CR 4a R 5a ) m -G 1 , —CR 4a ═CR 5a -G 1 , —(CR 4a R 5a ) m -G 2 , —CR 4a ═CR 5a -G 2 , or haloalkyl, or R 13  and R 14  taken together with the carbon atoms to which they are attached form a substituted or unsubstituted phenyl or heteroaryl ring. 
     
     
         15 . The compound of  claim 1 , wherein the compound is selected from the group consisting of:
 trans-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-1,2,3,3a,5,6-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-4(10bH)-one;   trans-2-(2,5-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trains-2-(3,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-methylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,3-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   3-((trans-6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-2(3H)-yl)methyl)benzonitrile;   trans-2-(2,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(naphthalen-1-ylmethyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-10-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-7-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8,9-dichloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[34-e]azepin-6(10bH)-one;   trans-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-methyl-3-((6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-2(3H)-yl)methyl)benzoate;   trans-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(5-chloro-2-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3,4-difluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(trifluoromethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(naphthalen-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-m-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-p-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-styryl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-phenyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-phenethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-methyl 2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;   trans-10-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-9-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-7-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8,10-dimethoxy-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8,10-dimethoxy-1,2,3,3 a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-benzyl-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bR)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-7-phenyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bR)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-hydroxy-1,2,3,3 a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(piperidine-1-carbonyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-N,2-dimethyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-phenethyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-(3-(trifluoromethyl)phenethyl)-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-phenyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-methyl 2-benzyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;   cis-2-benzyl-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-isobutoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-(1,3,4-oxadiazol-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-isopropylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-ethylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(pyridin-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-(trifluoromethyl)benzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((R)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((S)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bR)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bR)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8,10-difluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-fluoro-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-sec-butoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isobutoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(cyclohexylmethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2,6-difluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(isopentyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-sec-butoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(isopentyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isobutoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(cyclohexylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(pyri din-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxypyrimidin-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(thiophen-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-methoxy-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-methoxy-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(1-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(benzo[e][1,2,5]oxadiazol-5-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isopropyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(2-methylprop-1-enyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-3-(2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepin-8-yl)benzaldehyde;   (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclopentenyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3,3,3-trifluoroprop-1-en-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(5-methylfuran-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclohexyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclopentyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3,5-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2,6-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3,4-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2,3-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-8-(2,3,6-trifluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bR)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(methyl sulfonyl)phenyl)-1,2,3,3a, 4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bR)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   N,N-dimethyl-3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzamide;   trans-8-(2-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(2-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one hydrochloride;   trans-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;   3-(trans-2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;   trans-8-(3,6-dihydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(4-fluorophenoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-isobutyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3,5-dimethylisoxazol-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4,4-dimethylcyclohexyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-((S)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-((R)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(ethyl sulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(ethylsulfonyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2,6-difluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(cyclopropylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one; and   cis-8-fluoro-9-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(1bH)-one;   or a pharmaceutically acceptable salt thereof.   
     
     
         16 .- 17 . (canceled) 
     
     
         18 . The compound according to  claim 13 , wherein the compound is:
 trans-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,5-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,5-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,4-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-methylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,3-dimethylbenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-methoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3-fluorobenzyl)-1,2,3,3 a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(2-fluorobenzyl)-1,2,3,3 a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   3-((trans-6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-2(3H)-yl)methyl)benzonitrile;   trans-2-(2,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(3,5-dimethoxybenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3,5-dichlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3-chlorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(3-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-(naphthalen-1-ylmethyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-10-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-7-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-9-chloro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8,9-dichloro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-2-benzyl-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-benzyl-8-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-fluoro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-9-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   cis-2-benzyl-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[34-e]azepin-6(10bH)-one;   trans-10-fluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-methyl-3-((6-oxo-1,3a,4,5,6,10b-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-2(3H)-yl)methyl)benzoate;   trans-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-(5-chloro-2-fluorobenzyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3,4-difluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(trifluoromethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(naphthalen-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-m-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-p-tolyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(methyl sulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-styryl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-phenyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-phenethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-methyl 2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;   trans-10-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-9-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-7-fluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8,10-dimethoxy-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8,10-dimethoxy-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-benzyl-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-8,10-difluoro-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bR)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-7-(trifluoromethoxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-7-phenyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3 aR, 10bR)-8-(4-fluorophenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-hydroxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(piperidine-1-carbonyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-phenethoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorophenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-N,2-dimethyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-phenethyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-(3-(trifluoromethyl)phenethyl)-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-2-methyl-6-oxo-N-phenyl-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxamide;   trans-methyl 2-benzyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepine-8-carboxylate;   cis-2-benzyl-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-isobutoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-methoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-benzyl-8-(1,3,4-oxadiazol-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-isopropylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-ethylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(4-(trifluoromethoxy)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-amino-2-benzyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(pyridin-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   cis-8-amino-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-(trifluoromethyl)benzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((S)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((R)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((S)-1-phenylethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bR)-8-(4-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bR)-8-(3-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8,10-difluoro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-fluoro-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-sec-butoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isobutoxy-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(cyclohexylmethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2,6-difluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(isopentyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-sec-butoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(isopentyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isobutoxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-methoxyphenethoxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-methoxyphenethoxy)-1,2,3,3 a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(cyclohexylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(pyridin-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxypyrimidin-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3 aR,10bS)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-(2-fluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aR,10bS)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2-methoxyphenethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(thiophen-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-methoxy-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-methoxy-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(1-hydroxyethyl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxypropan-2-yl)phenyl)-2,5-dimethyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(benzo[e][1,2,5]oxadiazol-5-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-isopropyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(2-methylprop-1-enyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-3-(2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[e]pyrrolo[3,4-c]azepin-8-yl)benzaldehyde;   (3aS,10bS)-8-chloro-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-hydroxy-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclopentenyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(3,3,3-trifluoroprop-1-en-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-2-methyl-8-(5-methylfuran-2-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclohexyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-cyclopentyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3,5-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   3aS,10bS)-8-(2,6-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3,4-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(4-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2,3-difluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-8-(2,3,6-trifluorobenzyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-fluorobenzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-benzyl-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3 aR,10bS)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-(4-fluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bS)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bR)-8-fluoro-5-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(methyl sulfonyl)phenyl)-1,2,3,3a, 4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aR,10bR)-2-methyl-8-(3-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   N,N-dimethyl-3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzamide;   trans-8-(2-(methylsulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(2-(methyl sulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-acetylphenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one hydrochloride;   trans-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   3-(trans-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;   3-(trans-2-methyl-6-oxo-1,2,3,3a,4,5,6,10b-octahydrobenzo[c]pyrrolo[3,4-e]azepin-8-yl)benzonitrile;   trans-8-(3,6-dihydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3,6-dihydro-2H-pyran-4-yl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(4-fluorophenoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-isobutyl-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3,5-dimethylisoxazol-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(4,4-dimethylcyclohexyloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-((S)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-((R)-1-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(3-(ethyl sulfonyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(2-hydroxyethyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(3-(ethylsulfonyl)phenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   trans-2-methyl-8-(tetrahydro-2H-pyran-4-yl)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one;   (3aS,10bS)-8-(benzyloxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(2-methoxyphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   trans-8-(2,6-difluorophenyl)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(cyclopropylmethoxy)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one;   (3aS,10bS)-8-(3-acetylphenyl)-2-methyl-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one; or   cis-8-fluoro-9-methyl-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(1bH)-one;   or a pharmaceutically acceptable salt thereof.   
     
     
         19 . The compound according to  claim 1  of formula (Ib): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or prodrug thereof, wherein
 R 20  is hydrogen or alkyl. 
 
     
     
         20 . The compound according to  claim 19 , wherein
 R 1  and R 3  are hydrogen; and   R 2  is hydrogen, alkyl, haloalkyl, —(CR 4a R 5a ) m -G 1  or —(CR 4a R 5a ) m -G 2 .   
     
     
         21 . The compound according to  claim 19 , wherein the compound is:
 trans-2-benzyl-1,2,3,3a,5,6-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-4(10bH)-one;   trans-1,2,3,3a,5,6-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-4(10bH)-one; or   trans-2-(2,3-dichlorophenylsulfonyl)-1,2,3,3a,5,6-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-4(10bH)-one;   or a pharmaceutically acceptable salt, amide or prodrug thereof.   
     
     
         22 .- 35 . (canceled) 
     
     
         36 . A method for treating conditions, disorders or deficits modulated by a 5-HT 2C  receptor, a 5-HT 6  receptor or both 5-HT 2C  and 5-HT 6  receptors wherein the condition, disorder or deficit is selected from the group consisting of a cognitive dysfunction, attention deficit/hyperactivity syndrome, personality disorders, affective disorders, motion or motor disorders, migraine, sleep disorders, feeding disorders, gastrointestinal disorders, diseases associated with neurodegeneration, addiction diseases, obesity, diabetes, psoriasis, and ocular hypertension, the method comprising administration of a therapeutically effective amount of the compound of  claim 15 , or a pharmaceutically acceptable salt, amide or prodrug thereof. 
     
     
         37 . A method for treating a disorder or condition modulated by the 5-HT 2C  receptor selected from the group consisting of bipolar disorder, depression, anxiety, schizophrenia, cognitive deficits of schizophrenia, obsessive compulsive disorder, migraine, epilepsy, eating disorders, obesity, diabetes, sexual dysfunction/erectile dysfunction, sleep disorders, psoriasis, Parkinson's disease, pain and spinal cord injury, pain, bladder dysfunction/urinary incontinence, smoking cessation, ocular hypertension, and Alzheimer's disease, said method comprising the step of administering to a subject in need thereof the compound of  claim 15 , or a pharmaceutically acceptable salt, amide or prodrug thereof. 
     
     
         38 . The method according to  claim 37  wherein the disorder modulated by the 5-HT 2C  receptor is schizophrenia or cognitive deficits of schizophrenia, said method comprising the step of administering to a subject in need thereof the compound of  claim 15 , or a pharmaceutically acceptable salt, amide or prodrug thereof. 
     
     
         39 . A method for treating a disorder modulated by the 5-HT 6  receptor selected from the group consisting of deficits in memory and cognition and learning, Alzheimer's disease, age-related cognitive decline, mild cognitive impairment, attention deficit/hyperactivity syndrome, schizophrenia, cognitive deficits of schizophrenia, depression, anxiety, obsessive compulsive disorders, Parkinson's disease, epilepsy, migraine, sleep disorders, anorexia, bulimia, irritable bowel syndrome, stroke, spinal or head trauma and head injuries, drug addiction, and obesity, said method comprising the step of administering to a subject in need thereof the compound of  claim 15 , or a pharmaceutically acceptable salt, amide or prodrug thereof. 
     
     
         40 . A pharmaceutical composition comprising a therapeutically effective amount of the compound of  claim 15 , or a pharmaceutically acceptable salt, amide or prodrug thereof, in combination with one or more pharmaceutically acceptable carriers. 
     
     
         41 .- 42 . (canceled)