Devices and methods for closure of transvascular or transcameral access ports

Abstract

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

What is claimed is: 
     
         1 . An implantable prosthesis comprising:
 a) an inflatable bioresorbable body having a proximal end and a distal end, the body being configured to be expanded radially by directing fluid into the body; and   b) at least one radially expandable strut attached to each of the proximal end and distal end of the body, each of the struts being configured to expand outwardly to prevent the prosthesis from being pulled through an anatomical opening into which it has been inserted.   
     
     
         2 . The prosthesis of  claim 1 , further comprising a coupling located at the proximal end of the prosthesis configured to be attached to a delivery system. 
     
     
         3 . The prosthesis of  claim 1 , wherein the coupling is configured to permit inflation fluid to pass therethrough. 
     
     
         4 . The prosthesis of  claim 1 , wherein the prosthesis defines a guidewire lumen therethrough. 
     
     
         5 . The prosthesis of  claim 4 , wherein the guidewire lumen defined in the prosthesis is configured to register with a guidewire lumen in the delivery system. 
     
     
         6 . The prosthesis of  claim 5 , wherein the struts extend from a radially central portion of the prosthesis to a radially outer periphery of the prosthesis. 
     
     
         7 . A method, comprising:
 a) providing a delivery system having a prosthesis removably attached to a distal end thereof;   b) delivering the delivery system over a guidewire routed to a target location within a patient's vasculature;   c) deploying the prosthesis at the target location to obstruct a vascular opening to be sealed;   d) detaching the prosthesis from the delivery system;   e) withdrawing the delivery system over the guidewire after the prosthesis has been detached therefrom;   f) advancing the delivery system toward the target location over the guidewire after the withdrawing step;   g) reattaching the prosthesis to the delivery system; and   h) performing a further step with the prosthesis.   
     
     
         8 . The method of  claim 7 , further comprising partially collapsing the prosthesis after the deploying step. 
     
     
         9 . The method of  claim 7 , further comprising at least partially repositioning the prosthesis after the deploying step. 
     
     
         10 . The method of  claim 7 , further comprising at least partially repositioning the prosthesis after the detaching step. 
     
     
         11 . The method of  claim 7 , further comprising collapsing and withdrawing the prosthesis into the delivery system. 
     
     
         12 . The method of  claim 7 , further comprising withdrawing the delivery system with the prosthesis attached thereto over the guidewire. 
     
     
         13 . A method, comprising:
 a) providing a delivery system having a prosthesis removably attached to a distal end thereof, the prosthesis being configured to radially self-expand into at least two axially spaced discs;   b) delivering the delivery system over a guidewire routed to a target location within a patient's vasculature;   c) deploying a first of said at least two discs proximate a first side of a first wall of an anatomical structure next to a vascular opening to be sealed;   d) deploying a second of said at least two discs proximate a second side of the first wall of the anatomical structure the prosthesis at the target location to obstruct the vascular opening;   e) applying tension to at least one tether routed through said at least two axially spaced discs to cause the prosthesis to collapse axially.   
     
     
         14 . The method of  claim 13 , wherein tension is applied to the at least one tether until leaks through the vascular opening are stopped. 
     
     
         15 . The method of  claim 13 , further comprising securing the at least one tether. 
     
     
         16 . The method of  claim 15 , wherein the at least one tether is secured by tying it off. 
     
     
         17 . The method of  claim 15 , wherein the at least one tether is secured by applying at least one clip to it.