Passion flower seed extract, and cosmetic, pharmaceutical or dermatological compositions containing same

Abstract

The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

1 - 12 . (canceled) 
     
     
         13 . A polyphenolic extract of seeds of passion flower, in particular of  Passiflora incarnata  or  Passiflora edulis , comprising at least 30 wt % polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract, and at least 10 wt % organic acids, relative to the weight of the dry extract. 
     
     
         14 . The extract of  claim 13 , comprising at least 35 wt % polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract. 
     
     
         15 . The extract of  claim 13 , wherein at least 50 wt % of said polyphenols are catechin derivatives, expressed as gallic acid equivalents, relative to the weight of polyphenols in the dry extract. 
     
     
         16 . The extract of  claim 13 , wherein said organic acids are acetic acid, malic acid, citric acid or mixtures thereof. 
     
     
         17 . The extract of  claim 13 , characterized in that it is obtained by solid/liquid extraction of passion flower seeds in a solvent selected from water, glycerols, glycols, and mixtures thereof. 
     
     
         18 . The extract of  claim 13 , characterized in that it is obtained by solid/liquid extraction of passion flower seeds in a solvent selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof. 
     
     
         19 . A method for preparing a polyphenolic extract of passion flower seeds as defined in  claim 13 , said method comprising at least one step of solid/liquid extraction in a solvent selected from water, glycerols, glycols, and mixtures thereof. 
     
     
         20 . The method of  claim 19 , characterized in that it comprises the following successive steps:
 a) grinding the seeds;   b) optionally defatting the seeds, preferably by pressing, by ethanolic extraction or by supercritical CO 2  extraction;   c) solid/liquid extraction of the ground and optionally defatted seeds in a solvent selected from water, glycerols, glycols, and mixtures thereof;   d) separating the solid phase and the liquid phase by decantation, and/or centrifugation and/or successive filtrations; and   e) optionally drying the extract obtained in step d).   
     
     
         21 . The method of  claim 19 , characterized in that said solid/liquid extraction solvent is selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof. 
     
     
         22 . A composition comprising as active principle a polyphenolic extract of passion flower seeds comprising at least 30 wt % polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract, and at least 10 wt % organic acids, relative to the weight of the dry extractor an extract obtainable by the method of  claim 19 , and a suitable excipient. 
     
     
         23 . The composition of  claim 22 , comprising from 0.001 to 10 wt %, advantageously from 0.01 to 5 wt %, of said polyphenolic extract of passion flower seeds, the weight of the extract being expressed as dry extract, relative to the total weight of the composition. 
     
     
         24 . A method for preventing and/or treating:
 disorders or pathologies of the skin and/or of the mucous membranes and/or of the skin appendages, advantageously inflammatory reactions, oxidation reactions, disorders relating to radical attacks optionally linked to pollution, disorders of the barrier or of homeostasis, of ageing, notably of chronological and/or actinic ageing, of the skin and/or of the mucous membranes and/or of the skin appendages, and/or   vascular disorders, and/or   damaged adipose tissue,   said method comprising the administration of a polyphenolic extract of seeds of passion flower comprising at least 30 wt % polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract, and at least 10 wt % organic acids, relative to the weight of the dry extract or an extract obtainable by the method of  claim 19  to a subject in need thereof.   
     
     
         25 . A method for cosmetic care of the skin and/or of the skin appendages and/or of the mucous membranes, for the purpose of improving the condition and/or the appearance thereof, consisting in administering a polyphenolic extract of seeds of passion flower comprising at least 30 wt % polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract, and at least 10 wt % organic acids, relative to the weight of the dry extractor an extract obtainable by the method of  claim 19 . 
     
     
         26 . The extract of  claim 13 , comprising at least 40 wt %, polyphenols, expressed as gallic acid equivalents, relative to the weight of the dry extract. 
     
     
         27 . The extract of  claim 13 , characterized in that it is obtained by solid/liquid extraction of passion flower seeds in a solvent selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof, in a proportion of 30% to 90% of glycerol and/or of glycol in water. 
     
     
         28 . The method of  claim 19 , characterized in that said solid/liquid extraction solvent is selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof in a proportion of 30% to 90% of glycerol and/or of glycol in water. 
     
     
         29 . The method of  claim 19 , characterized in that said solid/liquid extraction solvent is selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof in a proportion of 50% to 90% of glycerol and/or of glycol in water. 
     
     
         30 . The method of  claim 19 , characterized in that said solid/liquid extraction solvent is selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof in a proportion of 60% to 80% of glycerol and/or of glycol in water. 
     
     
         31 . The method of  claim 19 , characterized in that said solid/liquid extraction solvent is selected from the binary mixtures water/glycerol, water/glycol, and mixtures thereof in a proportion of 70% of glycerol and/or of glycol in water. 
     
     
         32 . The composition of  claim 22 , comprising from 0.01 to 5 wt %, of said polyphenolic extract of passion flower seeds, the weight of the extract being expressed as dry extract, relative to the total weight of the composition.