Micrornas and uses thereof

Abstract

Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods ad compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

1 . An isolated nucleic acid comprising a sequence selected from the group consisting of:
 (a) the sequence of a hairpin referred to in Table 1;   (b) the sequence of sequence identifiers 6757248-6894882 of the Sequence Listing of U.S. patent application Ser. No. 10/709,572;   (c) the sequence of sequence identifiers 1-6318 or 18728-18960 of the Sequence Listing of U.S. Provisional Patent Application No. 60/655,094;   (d) the sequence of a miRNA referred to in Table 1;   (e) the sequence of sequence identifiers 1-117750 or 6894883-10068177 of the Sequence Listing of U.S. patent application. Ser. No. 10/709,572;   (f) the sequence of sequence identifiers 6319-18727 or 18961-19401 of the Sequence Listing of U.S. Provisional Patent Application No. 60/655,094;   (g) the sequence of a target gene binding site referred to in Table 4;   (h) the sequence of sequence identifiers 117751-6757247 of the Sequence Listing of U.S. patent application Ser. No. 10/709,572;   (i) complement of (a)-(h);   (j) nucleotide sequence comprising at least 12 contiguous nucleotides at least 60% identical to (a)-(h);   wherein the nucleic acid is from 5-250 nucleotides in length.   
     
     
         2 - 17 . (canceled)