US2019015383A1PendingUtilityA1

Cannabinoid compositions and methods of preparation thereof

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Assignee: 5071 INCPriority: Jul 14, 2017Filed: Jul 13, 2018Published: Jan 17, 2019
Est. expiryJul 14, 2037(~11 yrs left)· nominal 20-yr term from priority
Inventors:Keith A. WoelfelJustin E. SingerJeremy H. GoldsteinMichael S. Brown
A23P 10/20A61K 47/10A61K 47/44A23L 2/52A23L 2/39A61K 47/12A61K 9/7007A61K 47/26A61K 9/1075A61P 25/04A61K 31/353A23L 33/105A23V 2002/00A23L 19/05A61K 47/42A61K 9/1664A61K 36/3482A61K 31/05A61K 31/658
42
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Claims

Abstract

Water-soluble cannabinoid compositions are described herein. The composition may include a cannabinoid mixture, e.g., purified from a cannabis extract, and one or more water soluble agents, such as a complex carbohydrate. Methods of preparing such compositions may include blending the cannabinoid mixture with the water soluble agents(s) in water to form an emulsion. Some methods include drying the emulsion to form a film coating or particles, such as spray-dried and/or agglomerated particles, wherein the film coating or particles are at least partially soluble in cold water.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A water soluble cannabinoid composition comprising:
 a purified cannabinoid mixture comprising at least 50% by weight tetrahydrocannabinol (THC), cannabidiol (CBD) or a mixture thereof, with respect to the total weight of the purified cannabinoid mixture;   at least one carrier oil; and   at least one water soluble agent chosen from a complex carbohydrate, a polyol, a polysaccharide, an oligosaccharide, or a combination thereof;   wherein the composition is soluble in water at a temperature less than or equal to about 20° C.; and   wherein the composition is in the form of agglomerated particles.   
     
     
         2 . The composition of  claim 1 , wherein the at least one water soluble agent comprises a starch, quillaja extract, maltodextrin, a sugar alcohol, or a combination thereof. 
     
     
         3 . The composition of  claim 2 , wherein the at least one water soluble agent comprises a modified food starch, sorbitol, or both. 
     
     
         4 . The composition of  claim 1 , wherein the composition has a bulk density ranging from about 0.3 g/cm 3  to about 0.7 g/cm 3 . 
     
     
         5 . The composition of  claim 1 , wherein at least 40% by weight of the agglomerated particles have a particle size between about 150 μm and about 800 μm. 
     
     
         6 . The composition of  claim 1 , wherein at least 60% by weight of the agglomerated particles have a particle size between about 150 μm and about 600 μm. 
     
     
         7 . The composition of  claim 1 , wherein the composition has a Hausner ratio less than or equal to 1.25, a compressibility index less than or equal to 20, or both. 
     
     
         8 . The composition of  claim 1 , wherein 400 mg of the composition dissolves in 240 ml of water at a temperature less than or equal to 20° C. within 20 seconds. 
     
     
         9 . The composition of  claim 1 , wherein the purified cannabinoid mixture comprises from about 0.1% to about 5.0% by weight terpene compounds, with respect to the total weight of the purified cannabinoid mixture. 
     
     
         10 . The composition of  claim 1 , wherein the purified cannabinoid mixture comprises CBD and THC in a weight ratio of CBD to THC ranging from about 20:1 to about 1:20. 
     
     
         11 . The composition of  claim 1 , wherein the composition comprises from about 0.05% to about 35.0% by weight of the purified cannabinoid mixture, with respect to the total weight of the composition. 
     
     
         12 . The composition of  claim 1 , wherein the composition comprises from about 25.0% to about 95.0% by weight of the at least one water soluble agent, with respect to the total weight of the composition. 
     
     
         13 . The composition of  claim 1 , wherein the composition further comprises at least one antioxidant, flavoring agent, sweetener, coloring agent, food preservative, or combination thereof. 
     
     
         14 . The composition of  claim 1 , wherein the purified cannabinoid mixture and the at least one carrier oil form a hydrophobic component of the composition, and a weight ratio of the at least one water soluble agent to the hydrophobic component ranges from about 1:5 to about 5:1. 
     
     
         15 . The composition of  claim 1 , wherein the at least one carrier oil comprises medium-chain triglyceride (MCT) oil, coconut oil, or long-chain triglyceride oil. 
     
     
         16 . A water soluble cannabinoid composition comprising:
 a purified cannabinoid mixture comprising at least 65% by weight tetrahydrocannabinol (THC), cannabidiol (CBD), or a mixture thereof, with respect to the total weight of the purified cannabinoid mixture;   at least one carrier oil comprising medium-chain triglyceride (MCT) oil or coconut oil; and   at least one water soluble agent chosen from a modified food starch, sorbitol, or a combination thereof;   wherein the composition is soluble in water at a temperature less than or equal to 20° C.; and   wherein the composition is in the form of agglomerated particles.   
     
     
         17 . The composition of  claim 16 , wherein the composition comprises from about 35.0% to about 95.0% by weight of the at least one water soluble agent, with respect to the total weight of the composition. 
     
     
         18 . The composition of  claim 16 , wherein 400 mg of the composition dissolves in 240 ml of water at a temperature less than or equal to 20° C. within 20 seconds. 
     
     
         19 . The composition of  claim 16 , wherein at least 40% by weight of the agglomerated particles have a particle size between about 150 μm and about 800 μm, and at least 60% by weight of the agglomerated particles have a particle size between about 150 μm and about 600 μm. 
     
     
         20 . The composition of  claim 16 , wherein the composition comprises, with respect to the total weight of the composition:
 from about 0.5% to about 25.0% by weight of the purified cannabinoid mixture;   from about 3.0% by weight to about 30.0% by weight of the at least one carrier oil; and   from about 40.0% to about 95.0% by weight of the at least one water soluble agent.   
     
     
         21 . A water soluble cannabinoid composition comprising:
 a purified cannabinoid mixture comprising tetrahydrocannabinol (THC) and cannabidiol (CBD) in a weight ratio of CBD to THC ranging from about 25:1 to about 1:25;   at least one carrier oil; and   at least two water soluble agents chosen from complex carbohydrates, polyols, polysaccharides, oligosaccharides, and combinations thereof;   wherein 400 mg of the composition dissolves in 240 ml of water at a temperature less than or equal to 20° C. within 20 seconds; and   wherein the composition is in the form of agglomerated particles.   
     
     
         22 . The composition of  claim 21 , wherein at least 50% by weight of the agglomerated particles have a particle size between about 150 μm and about 800 μm. 
     
     
         23 . The composition of  claim 21 , wherein the at least two water soluble agents comprise a starch and a sugar alcohol. 
     
     
         24 . The composition of  claim 21 , wherein the composition has a bulk density ranging from about 0.3 g/cm 3  to about 0.7 g/cm 3 . 
     
     
         25 . The composition of  claim 21 , wherein the purified cannabinoid mixture comprises less than 1.0% by weight terpene compounds. 
     
     
         26 . The composition of  claim 21 , wherein the composition further comprises at least one antioxidant, flavoring agent, sweetener, coloring agent, food preservative, or combination thereof. 
     
     
         27 . A water soluble cannabinoid composition comprising:
 a purified cannabinoid mixture comprising at least 80% by weight tetrahydrocannabinol (THC) or cannabidiol (CBD), with respect to the total weight of the purified cannabinoid mixture;   at least one carrier oil; and   at least two water soluble agents chosen from modified food starches, sugar alcohols, quillaja extract, maltodextrin, or combinations thereof;   wherein the composition is soluble in water at a temperature less than or equal to about 20° C.; and   wherein the composition is in the form of agglomerated particles.   
     
     
         28 . The composition of  claim 27 , wherein the at least two water soluble agents are present in the composition in an amount ranging from about 50.0% to about 95.0% by weight, with respect to the total weight of the composition. 
     
     
         29 . The composition of  claim 27 , wherein the composition has a bulk density ranging from about 0.4 g/cm 3  to about 0.7 g/cm 3 . 
     
     
         30 . The composition of  claim 27 , wherein at least 50% by weight of the agglomerated particles have a particle size between about 150 μm and about 600 μm.

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