Compositions and methods for treating beta-amyloid related diseases

Abstract

In alternative embodiments the invention provides compositions and methods for ameliorating diseases and conditions having a beta-amyloid component, including Alzheimer's disease (AD), Vascular Dementia (VD), dementia, pre-dementia, Cognitive Dysfunction Syndrome (CDS) and loss of cognition in humans and in non-human animal. In alternative embodiment the invention provides analogs of AB-007 and its acid form E64c (loxistatin), their preparation, and pharmaceutical compositions thereof and methods of making and using same. In alternative embodiments compositions of the invention are deuterated analogs of AB-007 (or E64d) and E64c (or loxistatin). In alternative embodiments compositions of the invention are metabolically blocked forms as compared to AB-007 and loxistatin. In alternative embodiments compositions of the invention are used to ameliorate (including treat, slow, reverse or prevent) a disease or condition which can be ameliorated by partial or complete inhibition of a cysteine protease, e.g., AD, VD, CDS. The invention also provides alternative dosage forms and formulations for AB-007 and loxistatin, and for compounds of this invention, which can be used e.g., to treat AD, VD and CDS, in humans and in non-human animals.

1 - 41 . (canceled) 
     
     
         42 : A method for treating or ameliorating, or treating the symptoms of, or being palliative for: a cognitive dysfunction or a loss of cognition, or a traumatic brain injury, comprising:
 administering or having administered to an individual in need thereof a pharmaceutical composition comprising a compound of Formula I:   
       
         
           
           
               
               
           
         
         wherein for both Formula I and Formula II, X 1  through X 11  are -D (deuterium) (positions X 1  through X 11  are deuterated), and X 12  through X 20  (Formula I) or X 12  through X 26  (Formula II) are —H (hydrogen). 
       
     
     
         43 : The method of  claim 42 , wherein for both Formula I and Formula II, X 1  through X 7  are -D (deuterium) (positions X 1  through X 7  are deuterated), and X 8  through X 30  (Formula I) or X 8  through X 26  (Formula II) are —H (hydrogen). 
     
     
         44 : The method of  claim 42 , wherein the compound of Formula I has a stereospecificity as set forth in Formula III: 
       
         
           
           
               
               
           
         
       
     
     
         45 : The method of  claim 44 , wherein the compound of Formula I or Formula II is conjugated to a chemical delivery system (CDS), or further comprises a chemical delivery system (CDS) selected from the group comprising a pyridinium, a 1,4 dihydrotrigonelline esters, or a dihydroquinoline or a dihydroisoquinoline,
 and optionally the pyridinium is selected from the group consisting of a 3-methyl-1-propylpyridinium, a 1-butyl-3-methylpyridinium and a 1-butyl-4-methylpyridinium.   
     
     
         46 : The method of  claim 42 , wherein compound of Formula I or Formula II is formulated in combination with, or together with, a selegiline, selegiline hydrochloride, or a deprenyl. 
     
     
         47 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated in unit dosage form,
 and optionally a unit dosage is between about 1 mg and about 400 mg; or is between about 1 mg and about 250 mg; or is about 5 mg and about 150 mg; or is between about 1 mg and about 75 mg; or is about 5 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, or about 75 mg.   
     
     
         48 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated for administration as a liquid dosage form or a solid dosage form, or for parenteral administration or enteral administration. 
     
     
         49 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated for administration as, or in the form of, an injectable sterile formulation, a gel, a lotion, a spray, an aerosol, a powder, a patch, an adhesive tape, a gel, a liquid, an elixir, a syrup, a suspension, a lyophilate, a lozenge, a pill, a geltab, a lozenge, a tablet, a capsule and/or an implant. 
     
     
         50 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated as a chow, or a feed or a feed supplement. 
     
     
         51 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated in combination with or together with a nutritional supplement or a vitamin. 
     
     
         52 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated in combination with or together with a non-steroidal anti-inflammatory drug. 
     
     
         53 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated in combination with or together with an antioxidant. 
     
     
         54 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated for administration as an implantable infusion system, and the compound is administered by an implantable infusion system. 
     
     
         55 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated with microencapsulation to delay disintegration and adsorption in the gastrointestinal tract to provide a sustained action over a longer period. 
     
     
         56 : The method of  claim 42 , wherein t wherein the compound of Formula I or Formula II is formulated with a time delay material, and optionally the time delay material comprises a glyceryl monostearate or a glyceryl distearate.
 wherein the compound of Formula I or Formula II is the composition is formulated with a solid or a liquid carrier.   
     
     
         58 : The method of  claim 42 , wherein the compound of Formula I or Formula II is formulated as or with: an aqueous or a non-aqueous solvent, an aqueous or a non-aqueous solution, a suspension, an emulsion or a solid,
 and optionally the non-aqueous solvent comprises a propylene glycol, a polyethylene glycol, a vegetable oil, an injectable organic ester,   and optionally the aqueous carrier comprises water, an ethanol, an alcoholic/aqueous solution, a glycerol, a saline or a buffered media.   
     
     
         59 : The method of  claim 42 , wherein the compound of Formula I or Formula II is:
 (a) formulated in a liposome;   (b) administered using an implant, an osmotic pump, an implantable infusion system or an intrathecal catheter; or   (c) formulated as a pharmaceutical composition packaged in a blister pack, blister packettes, blister package, lidded blister, blister card, clamshell, tray or shrinkwrap.   
     
     
         60 : A method for treating or ameliorating, or treating the symptoms of, or being palliative for: a cognitive dysfunction or a loss of cognition, or a traumatic brain injury, comprising:
 administering or having administered to an individual in need thereof a pharmaceutical composition comprising a compound of Formula IV:   
       
         
           
           
               
               
           
         
         wherein R 1 , R 2 , R 3 , R 4 , and R 5  are -D (deuterium), and R 6 , R 7 , R 8 , R 9 , R 10  and R are —H (hydrogen). 
       
     
     
         61 : The method of claim  62 , wherein the compound of Formula IV R 1  through R 3  are -D (deuterium) and R 4  through R 10  are —H (hydrogen) and R is ethyl; or, the compound of Formula IV R 1  through R 3  are -D (deuterium) and R 4  through R 10  and R are —H (hydrogen).