Selective amplification of optical coherence tomography signals

Abstract

Presented is an optical coherence tomography system and method to increase imaging depth of optical coherence tomography (OCT) by selective amplification. In a swept-source OCT system with periodically linear wavenumber-vs-time characteristic, the signal in principle is summation of various sinusoidal signals with different frequencies. Each frequency component of the recorded signal carries reflectivity information for a certain depth of the analyzed object. At greater depth inside the analyzed object, the reflectivity information is generally weak due absorption and scattering. An analog or digital electronic circuit selectively filters and amplifies frequencies above some threshold, possibly up to another threshold. In this way, even small signals for relatively larger depths become detectable.

1 . A swept-source optical coherence tomography system for recording sub-surface structure of an analyzed object, said optical coherence tomography system comprising:
 a swept light source configured for generating coherent light with a wavenumber varying with time;   an interferometric system configured for splitting the generated light onto a reference arm and a sample arm, where the sample arm is for projecting light onto and receiving light from the analyzed object, and where the received light interferes with light returning from the reference arm to produce an interference signal;   a photo-detector configured for recording a photo-detector signal in response to the interference signal;   a signal processing unit configured for selectively amplifying a high wavenumber part of the recorded photo-detector signal and for generating a digitized signal from the selectively amplified photo-detector signal; and   a data processing unit configured for calculation of at least one A scan from the digitized signal.   
     
     
         2 . The optical coherence tomography system according to  claim 1 , wherein the signal processing unit comprises an analog processing unit configured for analog processing of the photo-detector signal, where the analog processing unit comprises at least one tunable band pass or high pass filter and at least one variable gain amplifier. 
     
     
         3 . The optical coherence tomography system according to  claim 2 , wherein the signal processing unit comprises a digitizer configured for digitizing the analog processed photo-detector signal. 
     
     
         4 . The optical coherence tomography system according to  claim 1 , where the swept light source comprises a laser that has an at least approximately periodically linear wavenumber-vs-time characteristic. 
     
     
         5 . The optical coherence tomography system according to  claim 1 , where the data processing unit is configured for computing the at least one A scan as a weighted sum of Fourier transforms of the digitized signal. 
     
     
         6 . The optical coherence tomography system according to  claim 1 , where the data processing unit is configured for computing the at least one A scan as a weighted series of readings of the digitized signal. 
     
     
         7 . The optical coherence tomography system according to  claim 5  or  6 , where the weights are determined from gain values of the variable gain amplifier. 
     
     
         8 . The optical coherence tomography system according to  claim 1 , comprising a precision amplifier to boost up the photo-detector signal before the photo-detector signal is processed by the signal processing unit. 
     
     
         9 . The optical coherence tomography system according to  claim 2 , comprising an oscillator that generates a signal with at least approximately the same frequency as the frequency of the band pass filter. 
     
     
         10 . The optical coherence tomography system according to  claim 2 , where the tunable band pass filter is tuned to different mid-point frequencies either continuously or sequentially. 
     
     
         11 . The coherence tomography system according to  claim 2 , where the tunable high pass filter is tuned to different corner frequencies either continuously or sequentially 
     
     
         12 . The optical coherence tomography system according to  claim 2 , where the variable gain amplifier is controlled by a control unit. 
     
     
         13 . The optical coherence tomography system according to  claim 12 , where the control unit control further is configured for controlling the tunable band pass or high pass filter. 
     
     
         14 . The optical coherence tomography system according to  claim 2 , comprising multiple pairs of band pass or high pass filters and variable-gain amplifiers, with all pairs operating in parallel. 
     
     
         15 . The optical coherence tomography system according to  claim 1 , wherein the interferometric system comprises a beam splitter for splitting the generated light into the reference arm and the sample arm. 
     
     
         16 . A method for obtaining an A scan of an analyzed object using swept-source optical coherence tomography, said method comprising:
 generating swept-wavenumber coherent light and splitting the light into a sample arm and a reference arm;   projecting a probe beam of the generated light onto the analyzed object and receiving light reflected from the analyzed object using the sample arm;   producing an interference signal by providing that the received light interferes with light returning from the reference arm;   using a photo-detector to record a photo-detector signal in response to the interference signal;   selectively amplifying a high wavenumber part of the recorded photo-detector signal and generating a digitized signal from the selectively amplified photo-detector signal; and   calculating at least one A scan from the digitized signal.   
     
     
         17 . The method according to  claim 16 , wherein selectively amplifying comprises analog processing of the recorded photo-detector signal using an analog processing unit comprising at least one tunable band pass or high pass filter and at least one variable gain amplifier, and digitizing the analog processed photo-detector signal.