Methods of treating an overweight or obese subject

Abstract

The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.

1 . A method of treating an overweight or obese human subject in need thereof, the method comprising: orally administering to the subject a pharmaceutical composition comprising about 0.001 mg/kg to about 1 mg/kg of body weight per day of a compound selected from the group consisting of fumagillin, fumagillol, and salts thereof, and a pharmaceutically acceptable excipient. 
     
     
         2 .- 17 . (canceled) 
     
     
         18 . A method for facilitating and maintaining weight loss in a subject, the method comprising: administering to the subject an amount of fumagillin, fumagillol, or fumagillin ketone, or derivatives thereof, or salts, esters or prodrugs of these, effective to result in weight loss in the subject; and administering a therapeutically effective amount of a weight loss agent to maintain a reduced weight in the subject. 
     
     
         19 . The method according to  claim 18 , wherein administering is simultaneously. 
     
     
         20 . The method according to  claim 18 , wherein administering is sequentially. 
     
     
         21 . The method according to  claim 20 , wherein the fumagillin, fumagillol, or fumagillin ketone, or derivatives thereof, or salts, esters or prodrugs of these are intravenously administered for a first period of time, and the weight loss agent is orally administered for a second period of time. 
     
     
         22 . The method according to  claim 18 , wherein the weight loss agent is selected from the group consisting of: serotonin and noradrenergic re-uptake inhibitors; noradrenergic re-uptake inhibitors; selective serotonin re-uptake inhibitors; and intestinal lipase inhibitors. 
     
     
         23 . The method according to  claim 18 , wherein the weight loss agent is selected from the group consisting of orlistat, sibutramine, methamphetamine, ionamin, phentermine, bupropion, diethylpropion, phendimetrazine, benzphetermine, and topamax.