Compositions comprising S-Adenosylmethionine and a gallic acid ester

Abstract

Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.

1 . A method of treating a disease or disorder comprising administering a composition comprising exogenous S-adenosylmethionine and at least one gallic acid ester to a patient in need thereof. 
     
     
         2 . The method of  claim 1 , wherein the at least one gallic acid ester is selected from the group consisting of ethyl gallate, propyl gallate and octyl gallate.