Tissue-integrating electronic apparatus

Abstract

Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

1 . (canceled) 
     
     
         2 . An apparatus, comprising:
 a tissue-integrating scaffold;   a flexible wire woven through the tissue-integrating scaffold; and   a light source disposed within the tissue-integrating scaffold and electrically coupled to the flexible wire.   
     
     
         3 . The apparatus of  claim 2 , wherein the flexible wire is a first flexible wire, the apparatus further comprising:
 a second flexible wire woven through the tissue-integrating scaffold; and   an optical detector disposed within the tissue-integrating scaffold and electrically coupled to the second flexible wire.   
     
     
         4 . The apparatus of  claim 2 , the apparatus further comprising:
 a sensing moiety disposed within the tissue-integrating scaffold, the light source configured to excite the sensing moiety, the sensing moiety configured to emit an optical signal associated with a quantity or concentration of an analyte in response to being excited by the light source.   
     
     
         5 . The apparatus of  claim 2 , wherein the flexible wire is a first flexible wire, the apparatus further comprising:
 a sensing moiety disposed within the tissue-integrating scaffold, the light source configured to excite the sensing moiety, the sensing moiety configured to emit an optical signal associated with a quantity or concentration of an analyte in response to being excited by the light source;   a second flexible wire woven through the tissue-integrating scaffold; and   an optical detector disposed within the tissue-integrating scaffold and electrically coupled to the second flexible wire, the optical detector configured to detect the optical signal emitted from the sensing moiety.   
     
     
         6 . The apparatus of  claim 2 , wherein the flexible wire is a first flexible wire, the apparatus further comprising:
 a sensing moiety disposed within the tissue-integrating scaffold, the light source configured to excite the sensing moiety, the sensing moiety configured to emit an optical signal associated with a quantity or concentration of an analyte in response to being excited by the light source;   a second flexible wire woven through the tissue-integrating scaffold; and   an optical detector disposed within the tissue-integrating scaffold and electrically coupled to the second flexible wire, the optical detector configured to detect the optical signal emitted from the sensing moiety, the optical detector configured to transmit an electrical signal associated with the quantity or concentration of the analyte via the second flexible wire.   
     
     
         7 . The apparatus of  claim 2 , wherein the tissue-integrating scaffold is constructed of a polymeric material. 
     
     
         8 . The apparatus of  claim 2 , wherein the tissue-integrating scaffold is a fabric. 
     
     
         9 . The apparatus of  claim 2 , wherein the tissue-integrating scaffold is porous and at least two pores of the tissue-integrating scaffold are interconnected. 
     
     
         10 . The apparatus of  claim 2 , further comprising a sensing moiety disposed within the tissue-integrating scaffold, the tissue-integrating scaffold being porous such that the tissue-integrating scaffold is configured to have capillaries grow into the tissue-integrating scaffold such that the sensing moiety is in close proximity to capillaries when the tissue-integrating scaffold is implanted into a tissue. 
     
     
         11 . An apparatus, comprising:
 a tissue-integrating scaffold;   a flexible wire woven through the tissue-integrating scaffold; and   an optical detector disposed within the tissue-integrating scaffold and electrically coupled to the flexible wire.   
     
     
         12 . The apparatus of  claim 11 , wherein the flexible wire is a first flexible wire, the apparatus further comprising:
 a second flexible wire woven through the tissue-integrating scaffold; and   a light source disposed within the tissue-integrating scaffold and electrically coupled to the first flexible wire.   
     
     
         13 . The apparatus of  claim 11 , the apparatus further comprising:
 a sensing moiety disposed within the tissue-integrating scaffold and configured to emit an optical signal associated with a quantity or concentration of an analyte, the optical detector configured to receive the optical signal and transmit, via the flexible wire, an electrical signal associated with the quantity or concentration of the analyte.   
     
     
         14 . The apparatus of  claim 11 , wherein the flexible wire is a first flexible wire, the apparatus further comprising:
 a second flexible wire woven through the tissue-integrating scaffold;   a light source disposed within the tissue-integrating scaffold and electrically coupled to the second flexible wire; and   a sensing moiety disposed within the tissue-integrating scaffold, the light source configured to excite the sensing moiety, the sensing moiety configured to emit an optical signal associated with a quantity or concentration of an analyte in response to being excited by the light source, the optical detector configured to detect the optical signal emitted from the sensing moiety and transmit an electrical signal associated with the quantity or concentration of the analyte via the first flexible wire.   
     
     
         15 . A system including the apparatus of  claim 11 , the system further comprising a light source disposed 1 millimeter or less away from the tissue-integrating scaffold, the light source configured to emit an optical signal to excite a sensing moiety disposed within the tissue-integrating scaffold. 
     
     
         16 . The apparatus of  claim 11 , wherein the optical detector is at least one of tissue-integrating or tissue-anchoring. 
     
     
         17 . The apparatus of  claim 11 , wherein the optical detector is an organic photodiode. 
     
     
         18 . An apparatus, comprising:
 a fabric, tissue-integrating scaffold; and   an electrode disposed within the tissue-integrating scaffold and configured to generate an electrical signal associated with a quantity or concentration of an analyte, the electrode including an enzyme layer and a diffusion limiting membrane layer.   
     
     
         19 . The apparatus of  claim 18 , wherein the fabric, tissue-integrating scaffold is an e-textile. 
     
     
         20 . The apparatus of  claim 18 , wherein the fabric, tissue-integrating scaffold is constructed of at least one polymer. 
     
     
         21 . The apparatus of  claim 18 , further comprising a flexible wire woven through the tissue-integrating scaffold, at least one of a light source or an optical detector electrically coupled to the flexible wire.