Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency

Abstract

Disclosed herein are therapeutic regimens for treating or ameliorating a visual disorder associate with an endogenous retinoid deficiency in a subject by administering a therapeutically effective amount of a synthetic retinal derivative or a pharmaceutically acceptable composition comprising a synthetic retinal derivative according to the therapeutic regimen which leads to local recovery of visual functions such as visual fields, visual acuity and retinal sensitivity, among others.

1 . A method for treating a patient suffering from the loss or impairment of vision caused by a retinoid deficiency disorder, comprising the steps of:
 a) administering to the patient an initial therapeutically effective dose of a synthetic retinal derivative that provides replacement for endogenously produced 11-cis-retinal,   b) refraining from administering to the patient an additional therapeutically effective dose of synthetic retinal derivative for a resting interval of at least 1 month,   c) administering to the patient an additional therapeutically effective dose of a synthetic retinal derivative.   
     
     
         2 - 33 . (canceled) 
     
     
         34 . A kit for use in the treatment or amelioration of a visual disorder associated with an endogenous retinoid deficiency in a subject, the kit comprising:
 (i) a therapeutic effective amount of a synthetic retinal derivative, or a therapeutic effective amount of a pharmaceutically acceptable composition comprising a synthetic retinal derivative; and   (ii) instructions for administering the synthetic retinal derivative or the pharmaceutically acceptable composition to the subject   
     
     
         35 . A method of preparing a medicament for administration to a subject having an endogenous retinoid deficiency, the method comprising formulating a synthetic retinal derivative with a pharmaceutically acceptable vehicle.