6-amino-purin-8-one compounds

Abstract

wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

What is claimed is: 
     
         1 . A method of treating or preventing allergic disease, inflammatory disease, or autoimmune disease in a human subject in need thereof, the method comprising administering to the human an agent that is useful in the treatment or prevention of allergic disease, inflammatory disease, or autoimmune disease, and a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 R 1  is (1S)-1-methylbutyloxy; 
 m is an integer having a value of 4 to 6; 
 n is an integer having a value of 2 to 4; 
 
         or a salt thereof. 
       
     
     
         2 . The method according to  claim 1  wherein the compound is selected from the group consisting of:
 6-amino-2-{[(1 S)-1-methylbutyl]oxy}-9-[4-(1-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one; 
 6-amino-9-[4-(hexahydro-1H-azepin-1-yl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-7,9-dihydro-8H-purin-8-one; 
 6-amino-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-2-{[(1S)-1-methylbutyl]oxy}-7,9-dihydro-8H-purin-8-one; and 
 6-amino-2-{[(1 S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one. 
 
     
     
         3 . The method according to  claim 1  wherein the salt is a pharmaceutically acceptable salt. 
     
     
         4 . The method according to  claim 1  wherein the compound is a free base. 
     
     
         5 . The method according to  claim 1  wherein the agent that is useful in the treatment or prevention of allergic disease, inflammatory disease, or autoimmune disease is antigen immunotherapy, an anti-histamine, a steroid, an NSAID, a bronchodilator, methotrexate, a leukotriene modulator, monoclonal antibody therapy, receptor therapy, or an antigen non-specific immunotherapy. 
     
     
         6 . The method according to  claim 1  wherein the allergic disease, inflammatory disease, or autoimmune disease is asthma or rhinitis. 
     
     
         7 . A method of treating or preventing allergic disease, inflammatory disease, or autoimmune disease in a human subject in need thereof, the method comprising administering to the human an agent that is useful in the treatment or prevention of allergic disease, inflammatory disease, or autoimmune disease, and 6-amino-2-{[(1 S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one, or a salt thereof. 
     
     
         8 . The method according to  claim 7  wherein the salt is a pharmaceutically acceptable salt. 
     
     
         9 . The method according to  claim 7  wherein the compound is a free base. 
     
     
         10 . The method according to  claim 7  wherein the agent that is useful in the treatment or prevention of allergic disease, inflammatory disease, or autoimmune disease is antigen immunotherapy, an anti-histamine, a steroid, an NSAID, a bronchodilator, methotrexate, a leukotriene modulator, monoclonal antibody therapy, receptor therapy, or an antigen non-specific immunotherapy. 
     
     
         11 . The method according to  claim 7  wherein the allergic disease, inflammatory disease, or autoimmune disease is asthma or rhinitis.