Polymeric topical antiseptic compound and method of use

Abstract

Topical antiseptic rubs are disclosed that reduce microorganism loading on the skin surface preventing possible infections. The FDA currently recognizes ethanol, isopropanol and benzalkonium chloride as active ingredients but further defines the actives as chronic use drugs. The present invention describes formulations and applications of a liquid compound that forms a topical polymeric skin layer consisting of a given benzalkonium chloride concentration within the matrix, which quickly reduces all bacteria including the MERS, virus types, and kills spores including the Clostridium difficile . The “second skin” concept, is likened to the human skin cellular function of the stratum corneum, functions as a barrier to exogenous substances, which reduces any chronic flux of benzalkonium chloride into the epidermis and reducing symptoms of constant usage. The second skin polymeric application agglomerates, traps and kills bacteria. The “second skin” provides for cosmetic moisturizing, barrier effects and skin softness.

What is claimed is: 
     
         1 . A composition for use on mammals as a topical antiseptic rub, said composition comprising:
 (a) a polymeric skin scaffold selected from the group consisting of: polymers of 1-Octadecanaminium N,N dimethyl [(3-trihdroxysilyl) propyl] chloride, silk protein, polyhexanide and mixtures thereof said skin scaffold further including a monomeric coupling agent selected from the group consisting of of alkyl dialkylammonium trimethoxysilylpropyl chloride;   (b) an antimicrobial active selected from the group consisting of alkyldimethylbenzylammonium chloride of the formula   
       
         
           
           
               
               
           
         
       
       where n=8, 10, 12, 14, 16, 18;
 (c) a carrier for the polymers consisting of pharmaceutical grade water and surfactants selected from the group consisting of non-ionics, anionic, cationic, amphoteric and switterionic surfactants said surfactants also being suitable for emulsification of the composition; and 
 (d) a clay stabilizer for the trimethoxysilyl functional group. 
 
     
     
         2 . The composition of  claim 1 , further comprising a skin moisturizer selected from the group consisting of: Aloe Vera, Vitamin E acetate and mixtures thereof. 
     
     
         3 . The composition of  claim 1 , further comprising an amino acid selected from the group consisting of: arginine, allantoin, L-alanine and mixtures thereof. 
     
     
         4 . The composition of  claim 1 , further comprising an extracellular matrix comprising hyaluronic acid and sodium salts thereof. 
     
     
         5 . The composition of  claim 1 , optionally containing additional components selected from the group consisting of a citric acid buffer, a fragrance, UVA and UVB absorbers, UV luminescent dyes for detection under a black light monitor, viscosity modifiers selected from the group consisting of hydroxyethyl cellulose, xanthan gum or modifiers to make a sol gel and mixtures thereof. 
     
     
         6 . The composition of  claim 1 , wherein the polymeric skin scaffold forms a clear film of about 20-50 nm thickness which is plasticized with other components to form a flexible and lasting film. 
     
     
         7 . The composition of  claim 1 , wherein said composition is applied in effective amounts to agglomerate and kill spores. 
     
     
         8 . The composition of  claim 1 , wherein said composition dries in 30-120 seconds and displays activity against bacteria, virus, fungi, spores on human skin in about 15 seconds to about 10 minutes. 
     
     
         9 . The composition of  claim 1 , wherein said composition improves skin softness and retains skin moisture on males and females having aged skin of about >50 years. 
     
     
         10 . The composition of  claim 1 , wherein said composition reduces the skin flux of the benzalkonium chloride. 
     
     
         11 . The composition of  claim 1 , wherein said composition extends the protection of the person treated with the topical antiseptic in hours as compared to minutes with alcohol. 
     
     
         12 . The composition of  claim 1 , wherein said composition reduces patient to health care worker transfer of pathogens. 
     
     
         13 . The composition of  claim 1 , wherein said composition reduces human bacterial generated odor and can be used as an odor masking agent. 
     
     
         14 . The composition of  claim 1 , wherein said composition reduces skin irritation due to benzalkonium chloride and can be used in larger concentrations. 
     
     
         15 . A composition for use on mammals as a topical antiseptic rub, said composition comprising:
 (a) a polymeric skin scaffold selected from the group consisting of: polymers of 1-Octadecanaminium N,N dimethyl [(3-trihdroxysilyl) propyl] chloride, silk protein, polyhexanide and mixtures thereof said skin scaffold further including a monomeric coupling agent selected from the group consisting of of alkyl dialkylammonium trimethoxysilyl propyl chloride; and   (b) an extracellular matrix comprising hyaluronic acid and sodium salts thereof.   
     
     
         16 . The composition of  claim 15 , further comprising an antimicrobial active selected from the group consisting of alkyldimethylbenzylammonium chloride of the formula 
       
         
           
           
               
               
           
         
         where n=8, 10, 12, 14, 16, 18 and mixtures thereof. 
       
     
     
         17 . The composition of  claim 15 , further comprising a carrier for the polymers consisting of pharmaceutical grade water and surfactants selected from the group consisting of non-ionics, anionic, cationic, amphoteric and switterionic surfactants said surfactants also being suitable for emulsification of the composition. 
     
     
         18 . The composition of  claim 15 , further comprising an amino acid selected from the group consisting of: arginine, allantoin, L-alanine and mixtures thereof. 
     
     
         19 . The composition of  claim 15 , further comprising an extracellular matrix comprising hyaluronic acid and sodium salts thereof. 
     
     
         20 . The composition of  claim 15 , optionally containing additional components selected from the group consisting of a citric acid buffer, a fragrance, UVA and UVB absorbers, UV luminescent dyes for detection under a black light monitor, viscosity modifiers selected from the group consisting of hydroxyethyl cellulose, xanthan gum or modifiers to make a sol gel and mixtures thereof.