Ionic liquid supported synthesis

Abstract

The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides.

1 - 31 . (canceled) 
     
     
         32 . A kit comprising at least one ionic liquid, wherein the ionic liquid is an organic salt comprising:
 a heterocyclic or substituted heterocyclic quaternary nitrogen-containing organic cation, a heterocyclic or substituted heterocyclic quaternary phosphonium containing organic cation, or a heterocyclic or substituted heterocyclic trivalent sulfonium containing organic cation, and   an anion balancing the charge on the organic cation,   and monomeric units selected from amino acids, saccharides and nucleotides.   
     
     
         33 . The kit of  claim 32 , suitable for producing an oligopeptide, an oligosaccharide or an oligonucleotide comprising at least 2 monomeric units. 
     
     
         34 . An article of manufacture comprising at least one ionic liquid, wherein the ionic liquid is an organic salt comprising:
 a heterocyclic or substituted heterocyclic quaternary nitrogen-containing organic cation, a heterocyclic or substituted heterocyclic quaternary phosphonium containing organic cation, or a heterocyclic or substituted heterocyclic trivalent sulfonium containing organic cation, and   an anion balancing the charge on the organic cation,   and further comprising monomeric units selected from amino acids, saccharides and nucleotides.   
     
     
         35 . The article of manufacture of  claim 34 , suitable for producing an oligopeptide, an oligosaccharide or an oligonucleotide comprising at least 2 monomeric units.