Monolithic composition for dual-rate release with high drug loading

Abstract

The present document describes a process for the preparation of a low functionalization polysaccharide having carboxyl groups, comprising a) swelling of a polysaccharide granule in boiling water or a water/polyol mixture, to obtain a swollen polysaccharide; b) partial gelatinization of said swollen polysaccharide in an alkaline solvent mixture of water and alcohol and/or polyol, to obtain a partially gelatinized polysaccharide; and c) partial functionalization of said partially gelatinized polysaccharide with a functionalizing agent, to obtain the low functionalization polysaccharide.

1 . A process for the preparation of a low functionalization polysaccharide having carboxyl groups, comprising:
 a) swelling of a polysaccharide granule in boiling water or a water/polyol mixture, to obtain a swollen polysaccharide;   b) partial gelatinization of said swollen polysaccharide in an alkaline solvent mixture of water and alcohol and/or polyol, to obtain a partially gelatinized polysaccharide;   c) low functionalization of said partially gelatinized polysaccharide with a functionalizing agent under alkaline conditions, to obtain said functionalized polysaccharide, wherein said functionalized polysaccharide has a degree of substitution of from about 0.1 to about 0.3.   
     
     
         2 . (canceled) 
     
     
         3 . The process of  claim 1 , wherein said polysaccharide is chosen from a starch, a cellulose, a chitosan, a guar gum, a gellan gum, a xanthan gum, an agar, an agarose, an arabic gum, a pullulan, a dextran, a dextrin, a maltodextrin, a cyclodextrin and/or chosen from modified polysaccharides such as hydroxypropyl starch, hydroxypropyl cellulose, hydroxypropyl methyl starch, hydroxypropyl methyl cellulose, ethyl-cellulose, methyl-cellulose, succinyl starch, octenyl starch and combinations thereof. 
     
     
         4 . The process of  claim 1 , wherein said polyol is from ethylene glycol, propylene glycol, glycerol, sorbitol or combinations thereof. 
     
     
         5 . The process of  claim 1 , wherein said an alkaline solvent mixture of water and alcohol is a binary solvent mixture of water and alcohol or ternary solvent mixture of water, alcohol and polyol. 
     
     
         6 . The process of  claim 5 , wherein said binary solvent mixture of water and alcohol comprises water and at least one of ethanol, methanol, isopropanol, or combinations thereof, and said ternary solvent mixture of water and alcohol comprises water, ethanol or methanol and propylene glycol or glycerol or propanol or combination thereof. 
     
     
         7 . (canceled) 
     
     
         8 . The process of  claim 5 , wherein said water or said alcohol is from about 5% to about 50% v/v of said binary or ternary solvent mixture. 
     
     
         9 . (canceled) 
     
     
         10 . The process of  claim 5 , wherein said polyol is from about 50% to about 95% v/v of said binary or ternary solvent mixture. 
     
     
         11 . The process of  claim 1 , wherein said functionalizing agent is sodium chloroacetate, succinic anhydride, n-Octenyl succinic anhydride, acrylic acid, and combinations thereof. 
     
     
         12 . (canceled) 
     
     
         13 . The process of  claim 1 , further comprising step c′) after step c):
 c′) complexation of said functionalized polysaccharide with a divalent cation chosen from calcium, magnesium, zinc, aluminum, copper, or combinations thereof. 
 
     
     
         14 . The process of  claim 1 , further comprising step d):
 d) filtration of said functionalized polysaccharide and resuspension in alcohol, to obtain a resuspended functionalized polysaccharide.   
     
     
         15 . The process of  claim 14 , further comprising step e):
 e) neutralization of said resuspended functionalized polysaccharide, to obtain a neutralized functionalized polysaccharide.   
     
     
         16 . The process of  claim 15 , further comprising step f):
 f) washing of said neutralized functionalized polysaccharide, to obtain a precipitated functionalized polysaccharide.   
     
     
         17 . The process of  claim 16 , further comprising step g):
 g) drying of said precipitated functionalized polysaccharide, to obtain a dried functionalized polysaccharide.   
     
     
         18 . The process of  claim 1 , wherein said functionalization is carboxymethylation. 
     
     
         19 .- 22 . (canceled) 
     
     
         23 . A monolithic solid dosage form for dual rate release of an active pharmaceutical ingredient, comprising a low functionalization polysaccharide prepared by the process of  claim 1 , an anionic polysaccharide complexed with a divalent cation, a disintegrating agent and said active pharmaceutical ingredient. 
     
     
         24 . The monolithic solid dosage form of  claim 23 , wherein said disintegrating agent is cross-linked povidone, cross-linked carmelose, starch glycolate, or combinations thereof. 
     
     
         25 . The monolithic solid dosage form  claim 23 , further comprising a sustained release agent. 
     
     
         26 . (canceled) 
     
     
         27 . The monolithic solid dosage form of  claim 25 , wherein said sustained release agent is a combination of arginine and/or lysine. 
     
     
         28 . The monolithic solid dosage form of  claim 23 , wherein said anionic polysaccharide complexed with a divalent cation has a degree of substitution of from about 0.5 to about 1.5 
     
     
         29 . The monolithic solid dosage form of  claim 23 , wherein said divalent cation is chosen from calcium, magnesium, zinc, aluminum, copper, or combinations thereof. 
     
     
         30 . (canceled)