Device and method for formulating particles at small volumes

Abstract

Methods and devices for making particles at small volumes.

1 . A method for making particles, comprising:
 (a) introducing a first stream comprising a first solvent into a channel; wherein the channel has a first region adapted for flowing one or more streams introduced into the channel and a second region for mixing the contents of the one or more streams; and wherein the first solvent comprises a therapeutic material and optionally one or more particle-forming materials;   (b) introducing a second stream comprising one or more particle-forming materials and optionally a therapeutic material in a second solvent into the channel to provide first and second streams and wherein the first and second solvents are not the same;   (c) flowing the one or more first streams and the one or more second streams from the first region of the channel into the second region of the channel such that the one or more first streams and the one or more second streams arrive at the second region for mixing at substantially the same time; and   (d) mixing the contents of the one or more first streams and the one or more second streams in the second region of the channel to provide a third stream comprising particles.