US2019084968A1PendingUtilityA1

Fumagillol heterocyclic compounds and methods of making and using same

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Assignee: ZAFGEN INCPriority: Aug 11, 2015Filed: Nov 20, 2018Published: Mar 21, 2019
Est. expiryAug 11, 2035(~9.1 yrs left)· nominal 20-yr term from priority
A61K 31/4155C07D 413/14C07D 487/08A61K 31/5377A61K 31/403C07D 491/107A61K 9/0019C07D 401/14C07D 405/14C07D 405/12A61K 31/4025C07D 491/048A61P 3/04A61K 31/4523C07D 413/08A61K 31/5383A61K 31/541A61K 31/496A61K 31/397C07D 417/14A61K 31/4427A61K 31/336C07D 491/08Y02A50/30
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Claims

Abstract

Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A compound represented by: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         2 . A pharmaceutical composition comprising a compound of  claim 1  or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. 
     
     
         3 . The composition of  claim 2 , wherein the composition is formulated as a unit dose. 
     
     
         4 . The composition of  claim 2 , wherein the composition is formulated for subcutaneous administration. 
     
     
         5 . The composition of  claim 2 , wherein the composition is formulated for intravenous administration.

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