Methods of treating acne

Abstract

A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.

1 .- 17 . (canceled) 
     
     
         18 . A method for treating acne in a human in need thereof, the method comprising administering orally to the human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that is 5 mg to 40 mg total daily dose of doxycycline. 
     
     
         19 . The method according to  claim 18 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount of 40 milligrams. 
     
     
         20 . The method according to  claim 19 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered by sustained release. 
     
     
         21 . The method according to  claim 20 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered once a day. 
     
     
         22 . The method according to  claim 18 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in a dose of 20 mg twice a day. 
     
     
         23 . The method according to  claim 18 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μg/ml. 
     
     
         24 . The method according to  claim 18 , wherein the method results in no reduction in skin microflora during a six month treatment. 
     
     
         25 . The method according to  claim 18 , wherein the doxycycline is doxycycline monohydrate. 
     
     
         26 . The method according to  claim 18 , wherein the doxycycline is doxycycline hyclate. 
     
     
         27 . A method for treating acne in a human in need thereof, the method comprising administering orally to the human doxycycline, or a pharmaceutically acceptable salt thereof, in an amount that (i) is 5 mg to 40 mg total daily dose of doxycycline and (ii) results in no reduction of skin microflora during a six-month treatment. 
     
     
         28 . The method according to  claim 27 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount of 40 milligrams. 
     
     
         29 . The method according to  claim 28 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered by sustained release. 
     
     
         30 . The method according to  claim 29 , wherein the doxycycline is administered once a day. 
     
     
         31 . The method according to  claim 27 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in a dose of 20 mg twice a day. 
     
     
         32 . The method according to  claim 27 , wherein the doxycycline, or a pharmaceutically acceptable salt thereof, is administered in an amount which provides a serum concentration in the range of about 0.1 to about 0.8 μg/ml. 
     
     
         33 . The method of according to  claim 27 , wherein the doxycycline is doxycycline monohydrate. 
     
     
         34 . The method of according to  claim 27 , wherein the doxycycline is doxycycline hyclate.