Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof

Abstract

The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

1 - 35 . (canceled) 
     
     
         36 . A transdermal delivery device comprising:
 a) a housing including   i) an external body shell comprising a fluid chamber assembly access cover movably engaged with the external body shell;   ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment; and   iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell;   wherein the vapor producing assembly compartment is located in between the open-ended delivery outlet and the cartridge retaining container; and   b) a vapor producing assembly including   i) a fluid chamber assembly comprising a fluid container and a removable fluid container cap; and   ii) a permeation valve configured to reduce the pressure of a gas removed from the compressed gas cartridge and delivered to the fluid chamber assembly;   wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment.   
     
     
         37 . The transdermal delivery device of  claim 36 , wherein the external covering shell defines the internal cartridge compartment. 
     
     
         38 . The transdermal delivery device of  claim 36 , wherein the device further includes a control switch assembly. 
     
     
         39 . The transdermal delivery device of  claim 38 , wherein the control switch assembly is a mechanical switch or an electronic switch. 
     
     
         40 . The transdermal delivery device of  claim 36 , wherein the compressed gas cartridge is a 16 g compressed gas cartridge. 
     
     
         41 . The transdermal delivery device of  claim 36 , wherein the compressed gas cartridge includes a compressed gas. 
     
     
         42 . The transdermal delivery device of  claim 41 , wherein the compressed gas is carbon dioxide. 
     
     
         43 . The transdermal delivery device of  claim 36 , wherein the permeation valve is configured to reduce gas pressure to below 40 psi. 
     
     
         44 . The transdermal delivery device of  claim 36 , wherein the permeation valve comprises at least one permeable member selected from rubber, cork, textile, porous polymer, densely sintered metal or combinations thereof. 
     
     
         45 . The transdermal delivery device of  claim 36 , wherein the fluid container includes water. 
     
     
         46 . A transdermal delivery device comprising
 a cylinder containing pressurized carbon dioxide;   a permeation valve configured to reduce the pressure of the pressurized carbon dioxide;   a chamber configured to supersaturate a liquid in the chamber with carbon dioxide thereby forming a therapeutic vapor; and   a treatment chamber configured to deliver the therapeutic vapor to an individual.   
     
     
         47 . A method of producing a substance comprising a supersaturated amount of dissolved gas, the method comprising the steps of:
 a) placing the substance in an air-tight container; and   b) exposing the substance to carbon dioxide, wherein upon exposure, the carbon dioxide dissolves into the substance in an amount greater than the substance could dissolve at 25° C. and 1 atm.   
     
     
         48 . The method of  claim 47 , wherein the substance is a liquid or a colloid. 
     
     
         49 . The method of  claim 48 , wherein the colloid is a foam, a liquid, an aerosol, an emulsion, a gel, or a sol. 
     
     
         50 . The method of  claim 48 , wherein the liquid is water at pH 4. 
     
     
         51 . The method of  claim 47 , wherein dissolved carbon dioxide is produced at a concentration of at least 600 ppm.